- Meeting abstract
- Open Access
Use of elder donors for cadaveric single kidney transplantation: a new evolution or an inacceptable risk?
© Melandro et al; licensee BioMed Central Ltd. 2011
- Published: 24 August 2011
- Graft Survival
- Graft Function
- Cerebrovascular Accident
- Aged Donor
- Young Donor
Organ shortage and long waiting times represent relevant issues in modern kidney transplantation . Expansion of the donor pool using Extended Criteria Donors (ECD) represents a way to partially resolve these limits. ECDs are defined by UNOS as ≥ 60-year aged donors or 50-59-year aged donors with at least 2 of 3 risk factors (pre-procurement serum creatinine >1.4 mg/dl, cerebrovascular accident and history of hypertension) . However, use of ECD seems to be related to worse results in terms of graft function and survival . Moreover, no data exist with regard to comparison between over-60 and 50-59-year aged donors. The aim of this study is to analyze the cohort of ECD transplants performed in our Department, evaluating the role of donor age on results.
From January 2004 to May 2009, 95 single kidney transplantations using ECDs were performed. The entire cohort was stratified in 2 groups: Group A (50-59 years, n=26) and Group B (≥ 60 years, n=69). Donor, recipient and transplant characteristics were compared using the chi-squared and the Mann-Whitney test. Patient and graft survival were analyzed by the Kaplan-Meier method and compared using the log-rank test.
Group A presented younger donors (55 vs 67 years) and recipients (53 vs 58 years), a higher number of donors with previous history of hypertension (92% vs 43%) and higher pre-harvesting creatinine values (1.2 vs 0.9 mg/dL). Post-transplant graft function did not present statistical differences. Five-year patient and graft survivals results were similar (Fig. 1).
- Sung RS, Guidinger MK, Lake CD, McBride MA, Greenstein SM, Delmonico FL, et al: Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transpl. 2005, 79: 1257-1261. 10.1097/01.TP.0000161225.89368.81.View ArticleGoogle Scholar
- Metzger RA, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM: Expanded criteria donors for kidney transplantation. Am J Transplant. 2003, 3 (suppl 4): 114-View ArticlePubMedGoogle Scholar
- Stratta RJ, Rohr MS, Sundberg AK, Farney AC, Hartmann EL, Moore PS, et al: Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality?. Ann Surg. 2006, 243: 594-601. 10.1097/01.sla.0000216302.43776.1a.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.