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- Open Access
Up to date in inhalation anaesthesia: the desflurane
© Caroleo et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
The use of halogenated anaesthetics in cardiac surgery is still controversial. Preconditioning and postconditioning are the well described mechanisms that explain the protective myocardial effect of specific drugs in order to prevent the occurrence and/or to reduce the size of a necrotic post-ischemic myocardial area : they play a well recognized role in the “protective effect” of the halogenated anaesthetics. Preconditioning and postconditioning protect the myocardial cell from oxidative stress and take place through the activation of specific receptors and second messengers systems . Desflurane has shown a higher preconditioning and postconditioning power that could be optimal at 6% of Minimum Alveolar Concentration (MAC) . The solubility of the halogenated anaesthetics can be altered during cardiac surgery: Desflurane has shown a rapid wash-in and wash-out profile in cardiac “on pump” surgery [5, 6].
Halogenated anaesthetics and especially desflurane protect myocardium from the peri-operative ischemic injury even in case of high risk elderly patients .
- Murry CE, Jennings NB, Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986, 74: 1124-1136.PubMedView ArticleGoogle Scholar
- Baines CP, Zhang J, Wang G-W, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P: Mitochondrial PKC ε and MAPK from signaling modules in the murine heart. Circ Res. 2002, 90: 390-97. 10.1161/01.RES.0000012702.90501.8D.PubMedView ArticleGoogle Scholar
- Guarracino F, Landoni G, Tritapepe L, Pompei F, Leoni A, Aletti G, Scandroglio AM, Maselli D, De Luca M, Marchetti C, Crescenzi G, Zangrillo A: Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study. J Cardiothorac Vasc Anaesth. 2006, 20 (4): 477-83. 10.1053/j.jvca.2006.05.012.View ArticleGoogle Scholar
- Zhou J, Lu J: Dynamic changes in blood Solubility of desflurane, isoflurane, and halothane during cardiac surgery. J Cardiothorac Vasc Anaesth. 2001, 15 (5): 555-9. 10.1053/jcan.2001.26529.View ArticleGoogle Scholar
- Mets B, Reich NT, Mellas N, Beck J, Park S: Desflurane pharmacokinetics during cardiopulmonary bypass. J Cardiothorac Vasc Anaesth. 2001, 15 (2): 179-82. 10.1053/jcan.2001.21945.View ArticleGoogle Scholar
- De Hert SG, Cromheecke S, ten Broecke PW, Mertens E, De Blier IG, Stockman BA, Rodrigus IE, Van der Linden PJ: Effects of propofol, desflurane, and sevoflurane on recovery of myocardial function after coronary surgery in elderly high-risk patients. Anesthesiology. 2004, 99 (2): 314-23. 10.1097/00000542-200308000-00013.View ArticleGoogle Scholar
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