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Table 3 Cognitive profile difference between cluster groups

From: Cluster analysis dissecting cognitive deficits in older adults with major depressive disorder and the association with neurofilament light chain

 

Cluster A (n=17)

Cluster B (n=37)

P value

Age (SD)

77.12 (8.75)

70.05 (7.10)

0.003**

Educational years (SD)

9.12(4.05)

11.30 (4.35)

0.087

Diagnosis group

 MDD

 MCI/AD

  

<0.001***

6

33

 

11

4

GDS-15 (SD)a

5.59 (4.80)

5.02 (3.98)

0.656

NfL levels (SD)

26.21 (16.59)

16.95 (10.19)

0.028*

MMSE (SD)a

21.59 (2.50)

27.73 (1.84)

<0.001***

 Orientation

7.24 (1.25)

9.70 (0.52)

<0.001***

 Attention and calculation

5.29 (1.16)

7.24 (1.04)

<0.001***

 Memory

1.12 (1.17)

2.32 (0.82)

<0.001***

 Language

4.71 (0.85)

4.76 (0.68)

0.292

 Comprehension

2.29 (0.92)

2.73 (0.51)

0.029*

 Construction

0.94 (0.24)

0.97 (0.16)

0.574

  1. MDD major depressive disorder, MCI mild cognitive impairment, AD Alzheimer’s disease, GDS-15 15-item Geriatric Depression Scale, NfL neurofilament light chain, MMSE Mini-Mental State Examination
  2. *p < 0.05
  3. **p < 0.01
  4. ***p < 0.001
  5. aAnalysis with non-parametric Wilcoxon rank sum test
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BMC Geriatrics

ISSN: 1471-2318

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