Table 1 The metabolic pathways identified in relation to the components of sarcopenia
Sarcopenia component | Metabolic pathways | Involved metabolites | P-Value | Details |
|---|---|---|---|---|
Hand grip strength (right) | Beta Oxidation of Very Long Chain Fatty Acids | L-Acetylcarnitine | 3.82E-02 | SMPDB |
Alanine Metabolism | Glycine | 4.11E-02 | SMPDB | |
Carnitine Synthesis | Glycine | 4.69E-02 | SMPDB | |
Walking pace | Alpha Linolenic Acid and Linoleic Acid Metabolism | Eicosapentaenoic acid; Docosapentaenoic acid (22n-6) | 3.41E-03 | SMPDB |
Fructose and Mannose Degradation | D-Fructose; D-Mannose | 1.04E-02 | SMPDB | |
Galactose Metabolism | D-Fructose; D-Mannose | 1.27E-02 | SMPDB | |
Fructose and mannose metabolism | D-Fructose; D-Mannose | 4.56E-04 | KEGG | |
Galactose metabolism | D-Fructose; D-Mannose | 8.41E-04 | KEGG | |
Amino sugar and nucleotide sugar metabolism | D-Fructose | 2.05E-03 | KEGG | |
Starch and sucrose metabolism | D-Fructose; D-Mannose | 3.39E-02 | KEGG | |
Appendicular lean mass | Carnitine Synthesis | L-Lysine; Oxoglutaric acid | 3.41E-03 | SMPDB |
Lysine Degradation | L-Lysine; Oxoglutaric acid | 5.34E-03 | SMPDB | |
Citric Acid Cycle | Citric acid; Oxoglutaric acid | 8.99E-03 | SMPDB | |
Fructose and Mannose Degradation | D-Fructose; D-Mannose | 1.04E-02 | SMPDB | |
Galactose Metabolism | D-Fructose; D-Mannose | 1.27E-02 | SMPDB | |
Warburg Effect | Citric acid; Oxoglutaric acid | 3.06E-02 | SMPDB | |
Biotin Metabolism | L-Lysine | 4.10E-02 | SMPDB | |
Malate-Aspartate Shuttle | Oxoglutaric acid | 4.10E-02 | SMPDB | |
Fructose and mannose metabolism | D-Fructose; D-Mannose | 2.23E-03 | KEGG | |
Citrate cycle (TCA cycle) | 2-Oxoglutarate; Citrate | 2.23E-03 | KEGG | |
Galactose metabolism | D-Fructose; D-Mannose | 4.07E-03 | KEGG | |
Alanine, aspartate and glutamate metabolism | 2-Oxoglutarate; Citrate | 4.38E-03 | KEGG | |
Amino sugar and nucleotide sugar metabolism | D-Fructose; D-Mannose | 9.73E-03 | KEGG | |
Biotin metabolism | L-Lysine | 3.76E-02 | KEGG |