Table 1 Demographics and clinicopathological profile of the considered CMM patients
| Â | Total | Â | CMM Patients by age groups | Â | P value i | Â | Â | Â |
|---|---|---|---|---|---|---|---|---|
N = 1,368 | < 65 N = 779 (56.9%) | 65–79 N = 408 (29.8%) | ≥ 80 N = 181 (13.2%) | All age groups | < 65 vs. 65–79 | < 65 vs. ≥80 | 65–79 vs. ≥80 | |
Sex | Â | Â | Â | Â | Â | Â | Â | |
 Male | 726 (53.1) | 371 (47.6) | 262 (64.2) | 93 (51.4) | < 0.001 | < 0.001 | 0.407 | 0.009 |
 Female | 642 (46.9) | 408 (52.4) | 146 (35.8) | 88 (48.6) | ||||
Primary CMM sitea | Â | Â | Â | Â | Â | Â | Â | |
 Lower limbs | 248 (18.9) | 155 (20.4) | 62 (16.2) | 31 (18.1) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
 Upper limbs | 172 (13.1) | 95 (12.5) | 46 (12.0) | 31 (18.1) | ||||
 Head | 151 (11.5) | 47 (6.2) | 68 (17.7) | 36 (21.1) | ||||
 Hands/feet | 63 (4.8) | 25 (3.3) | 19 (5.0) | 19 (11.1) | ||||
 Trunk | 680 (51.7) | 438 (57.6) | 188(49.1) | 54 (31.6) | ||||
CMM histotype | Â | Â | Â | Â | Â | Â | Â | |
 Superficial spreading | 948 (69.3) | 591 (75.9) | 269 (65.9) | 88 (48.6) | < 0.001 | < 0.001 | < 0.001 | 0.001 |
 Nodular | 206 (15.1) | 81 (10.4) | 72 (17.6%) | 53 (29.3) | ||||
 Lentigo maligna | 32 (2.3) | 8 (1.0) | 14 (3.4%) | 10 (5.5) | ||||
 Acral-lentiginous | 23 (1.7) | 11 (1.4) | 5 (1.2%) | 7 (3.9) | ||||
 Desmoplastic | 7 (0.5) | 1 (0.1) | 3 (0.7) | 3 (1.7) | ||||
 Spitzoid | 30(2.2) | 25 (3.2) | 5 (1.2) | 0 | ||||
 CMM not otherwise  specified | 122 (8.9) | 62 (8.0) | 40 (9.8) | 20 (11.0) | ||||
CMM thickness (Breslow)b | Â | Â | Â | Â | Â | Â | Â | |
 ≤ 1 | 787 (57.5) | 513 (65.9) | 210 (51.5) | 64 (32.4) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
 1–2 | 204 (14.9) | 131 (16.8) | 53 (13.0) | 20 (11.0) | ||||
 2–4 | 151 (11.0) | 59 (7.6) | 60 (14.7) | 32 (17.7) | ||||
 > 4 | 139 (10.2) | 39 (5.0) | 49 (12.0) | 51 (28.2) | ||||
 Median (Q1-Q3) | 0.7 (0.4–1.7) | 0.6 (0.4–1.2) | 0.9 (0.4–2.3) | 1.9 (0.6–4.9) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Clark’s levelsc |  |  |  |  |  |  |  | |
 I | 3 (0.3) | 2 (0.3) | 1 (0.3) | 0 | < 0.001 | < 0.001 | < 0.001 | 0.096 |
 II | 328(28.6) | 223 (33.1) | 77 (23.7) | 28 (19.2) | ||||
 III | 427 (37.3) | 283 (42.0) | 105 (32.3) | 39 (26.7) | ||||
 IV | 338 (29.5) | 155 (23.0) | 122 (37.5) | 61 (41.8) | ||||
 V | 49 (4.3) | 11 (1.6) | 20 (6.2) | 18 (12.3) | ||||
Growth patternd | Â | Â | Â | Â | Â | Â | Â | |
 Radial | 270 (25.1) | 183 (28.8) | 69 (22.2) | 18 (14.1) | < 0.001 | 0.073 | 0.002 | 0.073 |
 Vertical | 804 (74.9 | 452 (71.2) | 242 (77.8) | 110 (85.9) | ||||
CMM Ulceratione | Â | Â | Â | Â | Â | Â | Â | |
 Present | 251 (19.7%) | 94 (12.7) | 86 (23.1) | 71 (43.3) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
 Absent | 1023 (80.3) | 644 (87.3) | 286 (76.9) | 93 (56.7) | ||||
Mitotic count per HPFf | Â | Â | Â | Â | Â | Â | Â | |
 Median (Q1-Q3) | 1 (0–3) | 0 (0–2) | 1 (0–4) | 3 (0–8) | < 0.001 | 0.001 | < 0.001 | < 0.001 |
TILg | Â | Â | Â | Â | Â | Â | Â | |
 Present | 862 (73.2) | 520 (76.5) | 246 (70.7) | 96 (64.4) | 0.005 | 0.105 | 0.01 | 0.202 |
 Absent | 315 (26.8) | 160 (23.5) | 102 (29.3) | 53 (35.6) | ||||
TNM Stageh | Â | Â | Â | Â | Â | Â | Â | |
 I | 905 (68.0) | 588 (77.6) | 239 (60.4) | 78 (44.1) | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
 II | 218 (16.4) | 72 (9.5) | 80 (20.2) | 66 (37.3) | ||||
 III | 141 (10.6) | 72 (9.4) | 49 (12.4) | 20 (11.3) | ||||
 IV | 67 (5.0) | 26 (3.4) | 28 (7.1 | 13 (7.3) | ||||