Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria

Table 4 Stratified analyses of the associations between serum MMA concentrations and cognitive function among older patients with CKD

	CERAD-WL			AF test
	Standardized β, 95% confidence intervals	P	P for interaction	Standardized β, 95% confidence intervals	P	P for interaction
Sex			0.622			0.039
Male	-2.593 (-4.921, -0.265)	0.029		-2,73 (-5.458, -0.001)	0.05
Female	-2.456 (-5.942, 1.029)	0.166		-0.825 (-3.848, 2.198)	0.592
Hypertension			0.213			0.809
Yes	-0.983 (-3.308, 1.341)	0.406		-0.063 (-2.381, 2.255)	0.958
No	-4.809 (-8.726, -0.892)	0.017		-6.996 (-10.847, -3.145)	< 0.001
Diabetes			0.059			0.368
Yes	-5.092 (-8.871, -1.313)	0.009		-3.406 (-6.983, 0.171)	0.062
No	-1.278 (-3.61, 1.053)	0.281		-1.566 (-3.96, 0.828)	0.199
UACR level			0.01			< 0.001
30 mg/g < UACR < 300 mg/g	-1.881 (-4.193, 0.431)	0.111		-0.366 (-2.67, 1.938)	0.755
UACR > 300 mg/g	-2.733 (-7.31, 1.845)	0.238		-6.858 (-10.875, -2.842)	0.001
Vitamin B12			0.934			0.562
< 556 pg/ml	-3.129 (-5.742, -0.516)	0.019		-2.15 (-4.775, 0.475)	0.108
> 556 pg/ml	-0.083 (-3.723, 3.558)	0.964		0.061 (-4.074, 2.854)	0.729
GNRI			0.541			0.104
< 98	4.564 (-2.144, 11.272)	0.176		-8.62 (-14.399, -2.841)	0.004
> 98	-3.919 (-6.047, -1.791)	< 0.001		-1.452 (-3.739, 0.561)	0.147

AF, Animal Fluency; CERAD-WL, Consortium to Establish a Registry for Alzheimer’s Disease Word Learning test; UACR, urea albumin/creatinine ratio; GNRI, geriatric nutritional risk index

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