Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study

Table 2 Summary of the GWAS data used in the MR analyses

Phenotype	Sample size	Ancestry	Consortium/cohort	Year	PMID
Exposure
Leisure sedentary behavior
Watching television	408,815	European	UK Biobank	2020	32,317,632
Computer usage	408,815	European	UK Biobank	2020	32,317,632
Driving	408,815	European	UK Biobank	2020	32,317,632
Sleep status
Sleep duration	446,118	European	UK Biobank	2019	30,846,698
Snoring	359,916	European	UK Biobank	2019	30,804,565
Daytime napping	452,633	European	UK Biobank	2019	33,568,662
Outcome
Frailty index	175,226	European	UK Biobank and TwinGene	2021	34,431,594
Confounders
BMI	681,275	European	GIANT	2018	30,124,842
Alcohol consumption	941,280	European	GSCAN	2019	30,643,251
Smoking heaviness	377,334	European	GSCAN	2019	30,643,251

ISSN: 1471-2318