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Table 1 Characteristics of multivariate frailty indices used in previous frailty and falls prevention studies and in this study

From: Incorporating frailty to address the key challenges to geriatric economic evaluation

 

eFI [46]

BLSA FI [34, 43]

GLOW FI [35, 44]

ProAct65 + FI1 [45]

This study

Country

UK

China

Canada

England

England

Data source

Electronic health records

Cohort survey

Cohort survey

Cohort survey

Cohort survey

Total # of items

36

332

34

40

52

Mean (SD)

Men: 0.13 (0.09)

Women: 0.15 (0.10)

Men: 0.11 (0.10)

Women: 0.14 (0.12)

Women only: 0.24 (0.13)

Both sex: 0.16 (0.11)

Men: 0.11 (0.09)

Women: 0.13 (0.10)

Severity categories

[Fit] 0-0.12 (50%)

[Mild] > 0.12–0.24 (35%)

[Moderate] > 0.24–0.36 (12%)

[Severe] > 0.36 (3%)

[1] 0-0.03

[2] > 0.03–0.10

[3] > 0.10–0.20

[4] > 0.20–0.50

[5] > 0.50

[Robust] 0-0.20 (43.9%)

[Prefrail] > 0.20–0.35 (34.1%)

[Frail] > 0.35 (22.1%)

[Non-frail] 0-<0.25 (81.5%)

[Frail] > = 0.25 (18.5%)

[Fit] 0-0.10 (50%)

[Mild] > 0.10–0.23 (35%)

[Moderate] > 0.23–0.37 (12%)

[Severe] > 0.37 (3%)

Component items

Chronic diseases

(17) Anemia; Arthritis; AF; CBVD; CKD; Diabetes; Heart failure; Heart valve disease; Hypertension; Hypotension; IHD; Osteoporosis; PD; PVD; RD; Thyroid disease; Urinary system disease

(8) Arthritis; Cataract; CHD; Glaucoma; Hypertension; Stroke; Thyroid disease; TIA

(13) Cancer; Celiac disease; Chronic bronchitis; Crohn’s disease; Diabetes; Heart disease; High cholesterol; Hypertension; Multiple sclerosis; Osteoarthritis; PD; RA; Stroke

(15) Blood disease; Cancer; Digestive disease; Ear disease; Endocrine disease; Eye disease; Genitourinary disease; Heart disease; Infectious disease; Mental disease; MSKD; Nervous disease; RD; Skin disease; Other disease

(20) Angina; Arrhythmia; Arthritis; Asthma; Cancer; Cataract; Depression; Diabetes; DED; DKD; Glaucoma; Heart attack; Heart disease– other; Heart murmur; Hypertension; High cholesterol; Lung disease; MD; Osteoporosis; Stroke

Sensory/physical impairments and geriatric syndromes

(12) Hearing impairment; Visual impairment; Dizziness; Dyspnea; Falls; Foot problems; Fragility fractures; Peptic ulcer; Skin ulcer; Sleep disturbance; UI; Weight loss and anorexia

(5) Hearing problem; Use a hearing aid; Use a walking aid; Tremor; UI

(1) Unintentional weight loss

(2) Use a walking aid; Balance problems

(8) Seeing difficulties; Hearing difficulties; Slow walking speed;3,4 Balance problems;4 Weak grip strength;3,4 Weak leg strength;4 UI; Significant weight loss3,4

Cognitive impairment

(1) Memory and cognitive problems

(1) MMSE < 15

  

(1) Composite measure of cognitive problems across 4 tests of memory, mental speed and numeracy

Subjective symptoms and health status

 

(5) Lack of energy; Felt less useful; Don’t feel a lot of fun in life; Don’t feel very happy; Feel nothing to do

(6) Feels full of life; Has a lot of energy; Feels worn out; Feels tired; Self-rated health; Self-rated pain

(6) Feeling calm; Have a lot of energy; Feeling low; Social activity interfered by physical and emotional health; Self-rated health; Normal work interfered by pain

(4) Self-reported exhaustion;3 Self-rated health; Self-rated pain; Self-reported long-standing illness

Lifestyle risk factors

   

(2) Obesity (BMI > = 30); Low physical activity

(2) Low physical activity;3 Obesity

Activity limitation

(3) Any activity limitation; Housebound; Mobility and transfer problems

(14) ADL & IADL limitations

(12) ADL limitations

(14) ADL & IADL limitations

(15) ADL & IADL limitations

Healthcare contact

(2) Polypharmacy (5 + medications); Requirement for care

 

(2) Polypharmacy (5 + medications); Frequency of healthcare visit in past year

(1) Polypharmacy (6 + medications)

(1) Polypharmacy (5 + medications)

Social

(1) Social vulnerability

   

(1) Living alone

  1. Abbreviation: ADL: activities of daily living; AF: atrial fibrillation; BLSA: Beijing Longitudinal Study of Aging; CBVD: cerebrovascular disease; CHD: coronary heart disease; CKD: chronic kidney disease; DED: diabetic eye disease; DKD: diabetic kidney disease; eFI: electronic frailty index; FI: frailty index; GLOW: Global Longitudinal Study of Osteoporosis in Women; IADL: instrumental activities of daily living; IHD: ischemic heart disease; MD: macular degeneration; MMSE: mini-mental status examination; MSKD: musculoskeletal disease; PD: Parkinson’s disease; PVD: peripheral vascular disease; RA: rheumatoid arthritis; RD: respiratory disease; SD: standard deviation; TIA: transient ischemic attack; UI: urinary incontinence
  2. 1 The frailty index was constructed using data from the randomised controlled trial ProAct65 + which compared group- and home-based falls prevention exercise to usual care in London, Nottingham and Derby [47].
  3. 2 The original index contained 35 items including falls and fracture [43]; the latter were taken out from index and used as outcomes in subsequent study [34].
  4. 3 Components of the frailty phenotypes proposed by Fried and colleagues [27].
  5. 4 These variables had more than 5% missing values which were imputed by multivariate single imputation.