Table 2 The relationship between testosterone/estradiol levels and MMSE score in subgroups stratified by VRFs

Participants without VRF (N = 77)^b

Testosterone

 Model 1

Ref.

-1.28 (-5.10, 2.54)

0.98 (-2.34, 4.30)

0.18 (-3.03, 3.39)

0.65

 Model 2

Ref.

-1.32 (-5.25, 2.61)

0.72 (-3.01, 4.45)

-0.19 (-0.91, 3.52)

0.83

Estradiol

 Model 1

Ref.

1.91 (-1.39, 5.20)

0.95 (-2.44, 4.33)

1.26 (-1.83, 4.34)

0.56

 Model 2

Ref.

1.65 (-1.84, 5.14)

0.49 (-3.43, 4.40)

1.06 (-2.47, 4.59)

0.68

Participants with one VRF (N = 103)^c

Testosterone

 Model 1

Ref.

1.96 (-0.07, 4.00)

3.02 (0.83, 5.21)**

2.34 (-0.07, 4.75)

0.027

 Model 2

Ref.

1.57 (-0.50, 3.65)

2.74 (0.44, 5.03)*

2.21 (-0.52, 4.95)

0.07

Estradiol

 Model 1

Ref.

1.09 (-1.29, 3.48)

2.52 (0.40, 4.65)*

1.15 (-1.09, 3.38)

0.17

 Model 2

Ref.

0.34 (-2.16, 2.84)

1.75 (-0.46, 3.96)

0.16 (-2.39, 2.72)

0.66

Participants with two or more VRFs (N = 44)^c

Testosterone

 Model 1

Ref.

1.44 (-1.42, 4.30)

0.99 (-3.17, 5.15)

3.29 (-0.04, 6.62)

0.07

 Model 2

Ref.

1.82 (-0.93, 4.58)

0.82 (-3.18, 4.81)

3.01 (-0.33, 6.34)

0.19

Estradiol

 Model 1

Ref.

2.71 (-0.23, 5.65)

4.17 (1.20, 7.14)*

2.46 (-1.20, 6.12)

0.052

 Model 2

Ref.

3.03 (0.08, 5.99)

3.82 (0.82, 6.81)*

1.58 (-2.22, 5.38)

0.15