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Table 3 The independent associations of serum soluble alpha-klotho quartile and serum soluble alpha-klotho (continuous) with test-specific and global cognition z-scoresa

From: Serum soluble alpha-klotho klotho and cognitive functioning in older adults aged 60 and 79: an analysis of cross-sectional data of the National Health and Nutrition Examination Survey 2011 to 2014

  

Quartile 1

< 657.8pg/mL (n = 537)

Quartile 2

657.8 -797.7pg/mL (n = 510)

Quartile 3

797.8-958.2 pg/mL (n = 525)

Quartile 4

≥ 958.3 pg/mL (n = 601)

Continuous

β (95% confidence interval)

β (95% confidence interval)

β (95% confidence interval)

β (95% confidence interval)

β (95% confidence interval)

CERAD W-L immediate recall

Overall

-0.02

(-0.13, 0.10)

-0.07

(-0.21, 0.06)

-0.07

(-0.22, 0.08)

Reference

0.0001

(-0.00003, 0.0003)

Men

0.09

(-0.07, 0.26)

-0.06

(-0.28, 0.16)

0.03

(-0.16, 0.23)

Reference

0.0001

(-0.0001, 0.0003)

Women

-0.11

(-0.29, 0.06)

-0.08

(-0.20, 0.05)

-0.15

(-0.32, 0.02)

Reference

0.0001

(-0.00004, 0.0003)

CERAD W-L delayed recall

Overall

-0.08

(-0.23, 0.07)

-0.04

(-0.21, 0.13)

0.01

(-0.14, 0.15)

Reference

0.0001

(-0.0001, 0.0003)

Men

0.003

(-0.25, 0.26)

-0.02

(-0.30, 0.25)

0.07

(-0.13, 0.28)

Reference

-0.00001

(-0.0004, 0.0004)

Women

-0.16

(-0.35, 0.02)

-0.05

(-0.22, 0.12)

-0.05

(-0.22, 0.13)

Reference

0.0002

(-0.00004, 0.0004)

Digit Symbol Substitution Test

Overall

-0.13

(-0.25, -0.01)

-0.01

(-0.16, 0.14)

0.02

(-0.09, 0.12)

Reference

0.00003

(-0.0001, 0.0002)

Men

-0.08

(-0.24, 0.07)

0.01

(-0.17, 0.19)

0.10

(-0.06, 0.26)

Reference

-0.0001

(-0.0003, 0.0001)

Women

-0.16

(-0.32, -0.003)

-0.02

(-0.18, 0.14)

-0.05

(-0.18, 0.08)

Reference

0.0001

(-0.0001, 0.0003)

Animal fluency test

Overall

0.03

(-0.08, 0.14)

0.05

(-0.10, 0.19)

0.07

(-0.09, 0.22)

Reference

-0.0001

(-0.0003, 0.0001)

Men

0.14

(-0.05, 0.33)

-0.03

(-0.26, 0.21)

0.09

(-0.13, 0.30)

Reference

-0.0001

(-0.0004, 0.0002)

Women

-0.08

(-0.24, 0.07)

0.11

(-0.06, 0.27)

0.04

(-0.13, 0.21)

Reference

-0.00003

(-0.0003, 0.0002)

Global cognition

Overall

-0.05

(-0.14, 0.05)

0.003

(-0.14, 0.15)

0.03

(-0.10, 0.16)

Reference

0.00002

(-0.0001, 0.0002)

Men

0.05

(-0.12, 0.23)

-0.01

(-0.23, 0.20)

0.10

(-0.09, 0.28)

Reference

-0.00004

(-0.0003, 0.0002)

Women

-0.14

(-0.28, -0.01)

0.02

(-0.12, 0.16)

-0.03

(-0.17, 0.10)

Reference

0.0001

(-0.0001, 0.0003)

  1. a. The models were adjusted for age (years), sex (male or female), race/ethnicity (Mexican Americans, other Hispanics, non-Hispanic White, or non-Hispanic Black), education (below high school, high school graduate, or some college or above), depressive symptoms, smoking status (never, former, or current smokers), BMI (< 18.5 kg/m2, 18.5–24.9 kg/m2, 25-29.9 kg/m2, or ≥ 30 kg/m2), physical activity (hour of moderate to intense exercise per day), stroke (yes or no), prevalent coronary heart disease (CHD) (yes or no), total cholesterol (mg/dL), and systolic blood pressure (mmHg)
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BMC Geriatrics

ISSN: 1471-2318

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