Serum soluble alpha-klotho klotho and cognitive functioning in older adults aged 60 and 79: an analysis of cross-sectional data of the National Health and Nutrition Examination Survey 2011 to 2014

Table 2 Cognitive z-scores by quartile of serum soluble alpha-klotho

		< 657.8pg/mL	657.8 -797.8 pg/mL	797.8-958.3 pg/mL	≥ 958.3 pg/mL	P-value for ANOVA
Digit Symbol Test	Overall	0.24 (0.14, 0.35)	0.41 (0.29, 0.53)	0.48 (0.36, 0.60)	0.41 (0.29, 0.53)	0.0003
	Men	0.16 (0.02, 0.31)	0.26 (0.13, 0.39)	0.34 (0.21, 0.48)	0.20 (0.07, 0.33)	0.003
	Women	0.32 (0.19, 0.45)	0.56 (0.39, 0.72)	0.61 (0.46, 0.75)	0.56 (0.42, 0.71)	< 0.0001
CERAD W-L delayed recall	Overall	0.07 (-0.07, 0.21)	0.14 (-0.01, 0.29)	0.21 (0.06, 0.36)	0.19 (0.09, 0.30)	0.07
	Men	-0.02 (-0.23, 0.20)	-0.03 (-0.25, 0.19)	0.05 (-0.14, 0.25)	-0.02 (-0.15, 0.10)	0.44
	Women	0.15 (-0.01, 0.31)	0.30 (0.14, 0.46)	0.36 (0.20, 0.51)	0.35 (0.23, 0.48)	0.001
CERAD W-L immediate recall	Overall	0.18 (0.06, 0.30)	0.15 (0.03, 0.28)	0.21 (0.06, 0.36)	0.26 (0.13, 0.38)	0.29
	Men	0.10 (-0.05, 0.24)	-0.03 (-0.23, 0.17)	0.06 (-0.13, 0.26)	0.01 (-0.15, 0.17)	0.09
	Women	0.25 (0.10, 0.40)	0.33 (0.20, 0.47)	0.34 (0.19, 0.50)	0.44 (0.31, 0.56)	0.01
Animal fluency test	Overall	0.23 (0.12, 0.33)	0.30 (0.19, 0.42)	0.38 (0.23, 0.52)	0.23 (0.11, 0.35)	0.05
	Men	0.42 (0.25, 0.59)	0.27 (0.09, 0.44)	0.42 (0.21, 0.63)	0.25 (0.08, 0.41)	0.004
	Women	0.06 (-0.06, 0.17)	0.34 (0.17, 0.51)	0.33 (0.19, 0.48)	0.22 (0.08, 0.37)	< 0.0001
Global cognition	Overall	0.25 (0.14, 0.36)	0.35 (0.22, 0.48)	0.44 (0.29, 0.58)	0.35 (0.23, 0.47)	0.02
	Men	0.25 (0.09, 0.41)	0.20 (0.05, 0.35)	0.33 (0.14, 0.52)	0.17 (0.03, 0.32)	0.04
	Women	0.25 (0.11, 0.39)	0.50 (0.34, 0.67)	0.53 (0.39, 0.68)	0.48 (0.35, 0.61)	< 0.0001

ISSN: 1471-2318