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Table 3 Estimated marginal group means and p-values, based on mixed model analysis∗

From: The effect of ultraviolet irradiation compared to oral vitamin D supplementation on blood pressure of nursing home residents with dementia

 

1 month

3 months

6 months

p-value

Pt

Pgt

Estimated mean

Adjusted MD

p-value

Estimated mean

Adjusted MD

p-value

Estimated mean

Adjusted MD

p-value

Pg

score (95%CI)

(95%CI)

score (95%CI)

(95%CI)

score (95%CI)

(95%CI)

Systolic BP

 Main analysis

         

0.612

0.811

0.002

  UV (all), n = 23

117.4 (107.9, 126.8)

−26.0 (−39.9, −12.1)

.000

132.1 (122.8, 141.5)

4.5 (−6.8, 15.9)

0.432

128.3 (116.6, 139.9)

0.1 (−14.1, 14.3)

0.832

   

  VD1, n = 38

143.4 (133.6, 153.2)

  

127.6 (121.4, 133,6)

  

128.2 (120.2, 136.2)

    

 Additional analysis

         

0.256

0.642

0.064

  UV (> 3 months), n = 13

116.8 (103.5, 130.1)

−22.3 (−38.7, −5.9)

0.008

127.6 (117.0, 138.3)

−3.1 (−15.7, 9.6)

0.632

123.3 (109.2, 137.4)

−7.0 (−23.5, 9.4)

0.400

   

  VD2, n = 48

139.1 (129.5, 148.7)

  

130.7 (124.1, 137.4)

  

130.3 (121.9, 138.7)

    

Diastolic BP

 Main analysis

         

0.692

0.738

0.106

  UV (all), n = 23

69.4 (63.0, 75.7)

−10.0 (−19.2, −0.7)

0.035

77.3 (71.2, 83.7)

3.6 (−4.1, 11.2)

0.358

76.4 (68.7, 84.2)

2.7 (−6.8, 12.1)

0.580

   

  VD1, n = 38

79.3 (72.8, 85.9)

  

73.8 (69.6, 78.0)

 

73.8 (68.4, 79.1)

    

 Additional analysis

         

0.580

0.802

0.712

  UV (> 3 months), n = 13

70.0 (61.3, 78.7)

−6.6 (−17.4, 4.2)

0.227

75.7 (68.6, 82.8)

0.9 (−7.5, 9.3)

0.834

74.6. (65.3, 83.9)

0.9 (−10.0, 11.7)

0.878

   

  VD2, n = 48

76.6 (70.3, 82.9)

  

74.8 (70.3, 79.1)

 

73.7 (68.2, 79.3)

    

25(OH)D3

 Main analysis

         

0.037

0.230

0.006

  UV (all), n = 23

   

67.3 (58.3, 76.3)

- 5.9 (−17.3, 5.4)

0.299

64.0 (54.3, 73.5)

- 17.5 (−29.3, −5.7)

0.004

   

  VD1,n = 38

   

73.2 (66.8, 79.6)

 

81.4 (74.8, 87.9)

    

 Additional analysis

         

0.076

0.395

0.04

  UV (> 3 months), n = 13

   

67.5 (57.7, 77.2)

−5.3 (−16.9, 6.4)

0.368

64.6 (53.9, 75.3)

−15.0 (−27.4., −2.5)

0.019

   

  VD2, n = 48

   

72.7 (66.6, 78.9)

 

79.6 (73.3, 85.8)

    
  1. Systolic BP Systolic blood pressure, Diastolic BP Diastolic blood pressure, 25(OH)D3 serum 25-hydroxyvitamin D3
  2. *The mixed model analysis adjusted for the baseline of the outcome measures shows the p-values for the intervention (UVB) versus control (VD) condition UV (all): the group of the people, received any UVB radiation, VD1 group: people randomized in VD group plus the participants from the UV group who have refused irradiation UV (> 3 months): all participants having had UV exposure longer than 3 months, VD2 group: people randomized in the VD group plus all the participants from the UV group having had irradiation shorter than 3 months. Main analysis: VD1 - control group and UV (all) -intervention group, adjusted for the baseline of the outcome measures and skin type. Additional analysis: VD2 – control group and UV (> 3 months)) - intervention group, adjusted for the baseline of the outcome measures (Pg), the overall time effect (Pt) and the interaction effect of group and time (Pgt). The treatment effect is presented as adjusted mean difference (MD) between the VD and UV group for each time point with VD group as reference category
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BMC Geriatrics

ISSN: 1471-2318

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