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Table 3 Results of multivariable analyses to identify factors associated with hospitalizations for P&I as the primary diagnosis among U.S. long-term care facility residents, 2013–2015

From: Risk factors for pneumonia and influenza hospitalizations in long-term care facility residents: a retrospective cohort study

Characteristics

Short-staya

HR (99% CI)c

Long-stayb

HR (99% CI)c

Age group (ref = 65–74)

 75–84

1.08 (1.00, 1.17)

1.11 (1.06, 1.15)

 85+

1.16 (1.06, 1.27)

1.23 (1.18, 1.28)

Sex (ref = male)

0.84 (0.79, 0.89)

0.83 (0.80, 0.85)

Race and ethnicity

 Non-Hispanic White (ref = non-White)

1.00 (0.87, 1.15)

1.03 (0.97, 1.11)

 Non-Hispanic Black (ref = non-Black)

0.86 (0.72, 1.03)

0.89 (0.82, 0.97)

 Hispanic (ref = non-Hispanic)

1.02 (0.82, 1.27)

1.05 (0.95, 1.15)

Location resident is admitted from (ref = hospital)

 Community or home

0.81 (0.67, 0.98)

0.79 (0.76, 0.83)

 Another LTCF or swing bedd

0.99 (0.77, 1.26)

0.92 (0.87, 0.97)

 Other location

0.78 (0.60, 1.02)

0.86 (0.81, 0.93)

Type of admission is reentry (ref = new)

6.50 (6.09, 6.95)

1.43 (1.39, 1.47)

Body mass index, kg/m2 (ref = 18.5–24.9, normal)

  < 18.5, underweight

1.14 (1.03, 1.25)

1.05 (0.99, 1.11)

 25–29.9, overweight

0.88 (0.82, 0.95)

0.98 (0.95, 1.01)

  ≥ 30, obese

0.74 (0.68, 0.81)

0.98 (0.95, 1.02)

Current tobacco use (ref = no tobacco use)

0.87 (0.72, 1.06)

1.01 (0.95, 1.07)

Clinical Characteristics from MDS

 Cancer

1.20 (1.10, 1.32)

1.00 (0.94, 1.07)

 Atrial fibrillation or other dysrhythmias

1.13 (1.06, 1.21)

1.05 (1.01, 1.08)

 Coronary artery disease

1.00 (0.94, 1.07)

1.01 (0.98, 1.04)

 Heart failure

1.00 (0.92, 1.08)

1.13 (1.08, 1.18)

 Hypertension

1.02 (0.95, 1.10)

0.99 (0.96, 1.02)

 History of pneumonia

3.60 (3.36, 3.85)

1.38 (1.29, 1.46)

 Diabetes mellitus

0.98 (0.91, 1.05)

1.02 (0.99, 1.06)

 Arthritis

0.92 (0.85, 0.98)

0.95 (0.92, 0.98)

 Alzheimer’s disease

0.79 (0.67, 0.94)

0.89 (0.86, 0.93)

 Cerebrovascular accident, transient ischemic attack, or stroke

0.80 (0.72, 0.89)

0.89 (0.86, 0.93)

 Non-Alzheimer’s dementia

0.91 (0.84, 0.99)

0.87 (0.84, 0.89)

 Depression

0.98 (0.92, 1.05)

1.07 (1.05, 1.10)

 Asthma, chronic obstructive pulmonary disease, chronic lung disease

1.48 (1.38, 1.58)

1.56 (1.51, 1.61)

 Respiratory failure

1.11 (0.99, 1.24)

1.13 (1.03, 1.24)

 Parkinson’s disease

0.82 (0.69, 0.97)

0.95 (0.90, 1.00)

Geriatric Syndromes

 Cognitive Function Scale score (ref = no/mild impairment)

  Moderate cognitive impairment (2, 3)

0.95 (0.89, 1.02)

0.90 (0.87, 0.92)

  Severe cognitive impairment (4–6)

1.21 (1.01, 1.45)

0.92 (0.84, 1.01)

 Activities of Daily Living 28-point Scale score (ref = None to limited assistance required)

  Extensive assistance required (15–19)

1.56 (1.45, 1.68)

1.08 (1.05, 1.11)

  Extensive dependency (≥20)

1.91 (1.74, 2.08)

1.08 (1.04, 1.12)

 CHESS Scale score, overall health stability (ref = stable)

  Minimal instability (1, 2)

1.21 (1.12, 1.33)

1.09 (1.04, 1.14)

  Moderate to very high instability (3+)

1.04 (0.84, 1.28)

1.17 (1.04, 1.32)

 Charlson comorbidity score (MDS) (ref = 0)

  1–2

1.10 (0.96, 1.26)

1.04 (0.98, 1.10)

   ≥ 3

1.15 (0.99, 1.34)

1.12 (1.04, 1.19)

 Urinary or bowel incontinence (ref = none)

1.11 (1.04, 1.18)

0.99 (0.96, 1.02)

Shortness of breath

2.26 (2.09, 2.43)

1.34 (1.28, 1.39)

Swallowing disorder

0.91 (0.80, 1.03)

0.96 (0.89, 1.04)

Tube feeding

0.90 (0.76, 1.07)

1.30 (1.20, 1.41)

Ventilator or respirator use while in facility

1.48 (0.82, 2.67)

1.34 (1.03, 1.75)

Prognosis: less than 6 months to live

0.88 (0.61, 1.25)

0.80 (0.62, 1.04)

Medication Use 6 months before index

 Beers Criteria medication,e any use

1.09 (1.03, 1.16)

1.09 (1.06, 1.13)

 Antipsychotics, any use

0.86 (0.74, 1.01)

0.81 (0.77, 0.86)

 Opioid analgesics, any use

1.11 (1.01, 1.23)

0.97 (0.91, 1.03)

 Antibiotics,f any use

1.15 (1.08, 1.22)

1.30 (1.27, 1.34)

 Corticosteroids, any use

1.10 (1.00, 1.22)

1.10 (1.04, 1.17)

 Proton pump inhibitors, any use

1.04 (0.97, 1.12)

0.87 (0.84, 0.91)

Influenza vaccine received for season of cohort entry

0.99 (0.92, 1.05)

1.09 (1.06, 1.13)

Pneumococcal vaccination up to date

0.99 (0.92, 1.06)

1.06 (1.03, 1.10)

Health Service Use 6 months before index

 Any Hospitalizations

1.04 (0.92, 1.18)

0.91 (0.88, 0.94)

 Any ICU use

1.06 (0.99, 1.13)

1.06 (1.02, 1.11)

Facility Structural Characteristics

 Urban location (ref = non-urban)

0.87 (0.80, 0.93)

0.77 (0.74, 0.79)

 Total bed size (ref = < 100)

  100–200

0.94 (0.88, 1.01)

0.91 (0.88, 0.94)

   > 200

0.93 (0.82, 1.06)

0.89 (0.84, 0.94)

 For profit facility (ref = not for profit)

1.01 (0.90, 1.08)

1.05 (1.02, 1.08)

Facility Staffing Type and Hours

 Ratio of RN to RN + LPN (fifth vs. first quintile)

0.91 (0.81, 1.02)

0.90 (0.85, 0.95)

 SLP on-staff hours / 100 Beds (fifth vs. first quintile)

1.02 (0.94, 1.11)

0.99 (0.98, 1.00)

 LIP on-site (ref = none)

1.02 (0.96, 1.08)

0.93 (0.90, 0.95)

 Total nursing hours/resident/day (fifth vs. first quintile)

0.87 (0.78, 0.97)

0.99 (0.95, 1.04)

Facility Care Quality

 Antipsychotic use, % of residents (fifth vs. first quintile)

1.00 (0.90, 1.10)

1.07 (1.02, 1.11)

 Restraint use, % of residents (fifth vs. first quintile)

1.02 (0.94, 1.10)

1.07 (1.04, 1.11)

 Pressure ulcers, % of residents (fifth vs. first quintile)

0.96 (0.87, 1.05)

1.01 (0.96, 1.05)

  1. Values in boldface indicate statistically significant associations at the 0.01 level
  2. Abbreviations: LTCF long-term care facility, MDS Minimum Data Set, CHESS Changes in Health, End-stage disease and Symptoms and Signs, RN Registered Nurse, LPN Licensed Practical Nurse, SLP Speech Language Pathologist, LIP Licensed Independent Practitioner
  3. a N = 1,080,816 after 37,238 (3.3%) were excluded from regression due to missing data on facility-level variables
  4. b N = 571,694 after 21,749 (3.7%) were excluded from regression due to missing data on facility-level variables
  5. c We used robust Huber-White standard errors to account for clustering of residents within LTCFs
  6. d Swing beds are LTCF beds that can serve both short-stay and long-stay residents depending on need
  7. e The Beers criteria is a specific list of potentially inappropriate medications that are not recommended for use among older adults in most circumstances or under specific situations
  8. f Antibiotics recommended in the Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults