Certainty assessment | Summary of findings | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
№ of participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | Study event rates (%) | Anticipated absolute effects | ||
With NIE | With IE | Risk with NIE | Risk difference with IE | |||||||
WHOQOL-BREF – Overall | ||||||||||
5044 (5 observational studies) | not serious | serious a | not serious | not serious | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁⨁◯◯LOW | 3157 | 1887 | – | SMD 0.69 lower(0.93 lower to 0.46 lower) |
WHOQOL-BREF - General Health | ||||||||||
564 (3 observational studies) | very serious b | very serious a,c | not serious | serious d | strong associationall plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 425 | 139 | – | SMD 0.24 lower(1.0 lower to 0.52 higher) |
WHOQOL-BREF - Physical Health | ||||||||||
1120 (5 observational studies) | not serious | very serious a,c | not serious | not serious | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 683 | 437 | – | SMD 0.69 lower(1.17 lower to 0.22 lower) |
WHOQOL-BREF - Psychological Health | ||||||||||
1120 (5 observational studies) | not serious | very serious a,c | not serious | serious d | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 683 | 437 | – | SMD 0.82 lower(1.4 lower to 0.24 lower) |
WHOQOL-BREF - Social relationship | ||||||||||
1120 (5 observational studies) | serious e | serious a | not serious | serious d | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 683 | 437 | – | SMD 0.88 lower(1.46 lower to 0.29 lower) |
WHOQOL-BREF - Environmental area | ||||||||||
1120 (5 observational studies) | serious f | serious a | not serious | serious d | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 683 | 437 | – | SMD 0.66 lower(1.26 lower to 0.07 lower) |