A new age-related cutoff of medial temporal atrophy scale on MRI improving the diagnostic accuracy of neurodegeneration due to Alzheimer’s disease in a Chinese population

Table 1 Comparison of demographic factors and neuropsychological assessment between three groups

	NC (CDR = 0.0)	aMCI (CDR = 0.5)	DAT (CDR ≥ 1.0)	x²/F	p
	n = 87	n = 138	n = 71	x²/F	p
Sex(F/ M)	57/30	81/57	28/43	14.14	< 0.01
Age	65.49 (7.54)	66.22 (8.65)	71.10 (9.66)^##&&	17.69	< 0.01
Education	12.02 (3.15)	10.86 (3.52)*	11.43 (4.04)	5.80	0.055
MMSE	28.21 (2.94)	26.59 (1.93)**	15.28 (6.59)^##&&	169.31	< 0.01
ISR	26.80 (9.91)	12.86 (6.91)**	5.13 (6.81)^##&&	147.08	< 0.01
DSR	24.12 (10.76)	8.28 (7.22)	1.48 (3.76)^##&&	156.04	< 0.01
CDT	3.82 (0.63)	3.60 (0.64)*	1.85 (1.46)^##&&	115.14	< 0.01
TMT-A	55.07 (27.38)	71.703 (1.²⁵)**	126.16 (37.50)^##&&	80.45	< 0.01
TMT-B	101.07 (61.49)	137.04 (74.76)**	259.47 (82.62)^##&&	69.31	< 0.01
ADL	14.25 (1.65)	14.49 (2.82)	27.50 (9.69)^##&&	194.96	< 0.01
MTA	0.74 (0.62)	1.13 (0.92)*	2.26 (0.77)^##&&	115.19	< 0.01
MTAi	4.33 (2.87)	3.42 (2.14)	3.39 (1.87)	3.91	0.141
GCA	0.46 (0.50)	0.59 (0.54)	0.90 (0.53)^##&&	23.69	< 0.01
PA	0.61 (037)	0.65 (0.48)	0.59 (0.47)	1.12	0.571

Notes: ADL Instrumental Activities of Daily Living scale, aMCI amnestic Mild cognition impairment, CDT Clock drawing test, DAD Dementia of Alzheimer’s type, DSR Delayed story recall of the adult memory and Information processing battery, GCA global cortical atrophy scale, ISR Instant story recall of the adult memory and Information processing battery (AMIPB), MTA medial temporal atrophy scale, MTAi medial temporal atrophy index, MMSE Mini-mental state examination, NC Normal cognition, TMT-A Trail making test part A, TMT-B Trail making test part B, PA posterior atrophy.**P < 0.01 NC VS aMCI, *P < 0.05 NC VS aMCI; ^## P < 0.01 NC VS AD, ^&& P < 0.01 aMCI VS AD

ISSN: 1471-2318