Table 3 Changes in the CaMos Frailty Index (CFI) score per a 5-year period in participants aged 50+ years
Parameter | Women (N = 5566) | Men (N = 2187) | ||
|---|---|---|---|---|
Mean Estimate (95% CI) | Mean Estimate (95% CI) | |||
Time | Year 10 | −0.095 (−0.201; 0.010) | −0.008 (−0.010;-0.010) | |
Year 5 | −0.019 (−0.115;0.078) | −0.050 (−0.050;-0.050) | ||
Baseline (ref) | 0.000 | 0.000 | ||
Age, years | > = 80 | −0.005 (−0.073;0.063) | 0.061 (0.027;0.095) | |
65–80 | −0.030 (−0.097;0.037) | 0.059 (0.037;0.081) | ||
50–65 (ref) | 0.000 | 0.000 | ||
Time*age | Year 10 | > = 80 | 0.112 (0.003–0.220) | 0.078 (0.038;0.118) |
65–80 | 0.105 (−0.001;0.210) | 0.029 (0.020;0.037) | ||
50–65 (ref) | 0.000 | 0.000 | ||
Year 5 | > = 80 | 0.039 (−0.061;0.138) | 0.100 (0.060;0.139) | |
65–80 | 0.046 (−0.051;0.143) | 0.082 (0.075;0.089) | ||
50–65 (ref) | 0.000 | 0.000 | ||
Baseline (ref) | > = 80 | 0.000 | 0.000 | |
65–80 | 0.000 | 0.000 | ||
50–65 | 0.000 | 0.000 | ||
Prevalent fracture | NHNVF | 0.003 (−0.005;0.012) | 0.004 (−0.013;0.021) | |
Clinical VF | −0.011 (−0.034;0.012) | 0.044 (0.010;0.078) | ||
Hip | 0.029 (0.001;0.056) | 0.032 (−0.007;0.070) | ||
None (ref) | 0.000 | 0.000 | ||
Incident fracture | NHNVF | 0.013 (−0.002;0.029) | 0.034 (−0.006;0.073) | |
Clinical VF | 0.053 (0.022;0.084) | 0.010 (−0.066;0.086) | ||
Hip | 0.067 (0.026;0.109) | 0.121 (0.082;0.161) | ||
None (ref) | 0.000 | 0.000 | ||
Caucasian, yes | 0.003 (−0.011;0.017) | −0.006 (−0.029;0.017) | ||
Body mass index (BMI), kg/m2 | > = 40 | 0.071 (0.040;0.102) | 0.051 (0.025;0.078) | |
30–40 | 0.022 (0.013;0.030) | 0.020 (0.005;0.036) | ||
25–30 | 0.008 (0.001;0.014) | 0.010 (−0.002;0.021) | ||
<18.5 | −0.013 (−0.031;0.005) | 0.044 (−0.028;0.116) | ||
18.5–25 (ref) | 0.000 | 0.000 | ||
Physical activity (per 1000 kilocals/week) | −0.002 (−0.002;-0.001) | 0.000 (−0.001;0.001) | ||
Sedentary lifestyle, hours/day | 0.001 (0.000;0.002) | −0.002 (−0.004;0.000) | ||
Total calcium intake (per 1200 mg/day) | 0.003 (−0.003;0.009) | 0.002 (−0.009;0.012) | ||
Total vitamin D intake (per 800 /day) | 0.000 (−0.001;0.001) | −0.006 (−0.012;0.000) | ||
MMSE score (per 3.72 point change) | −0.010 (−0.017;-0.003) | −0.004 (−0.017;0.008) | ||
SF-36 - Physical subscale (per 5 unit change) | −0.031 (−0.032;-0.029) | −0.030 (−0.03;-0.03) | ||
SF-36 - Mental subscale (per 5 unit change) | −0.015 (−0.016;-0.013) | −0.018 (−0.021;-0.014) | ||
Education: University or higher, yes | −0.003 (−0.010;0.004) | −0.012 (−0.022;-0.001) | ||
Smoking | Never | −0.002 (−0.013;0.008) | −0.016 (−0.038;0.006) | |
Past | 0.010 (0.000;0.021) | −0.005 (−0.026;0.016) | ||
Current (ref) | 0.000 | 0.000 | ||
Alcohol, drinks per day | > = 3 | −0.016 (−0.046;0.014) | −0.015 (−0.036;0.006) | |
1 to 3 | −0.003 (−0.013;0.006) | −0.001 (−0.015;0.013) | ||
<1 to >0 | −0.007 (−0.013;−0.001) | 0.008 (−0.005;0.020) | ||
None (ref) | 0.000 | 0.000 | ||
Employment | Unemployed | -0.001 (−0.032;0.030) | −0.015 (−0.054;0.025) | |
Retired | −0.004 (−0.020;0.013) | −0.009 (−0.023;0.006) | ||
Homemaker | 0.002 (−0.015;0.018) | 0·00 | ||
Employed (ref) | 0.000 | 0·00 | ||
Living alone, yes | 0.003 (−0.003;0.009) | 0.015 (0.002;0.028) | ||
BMD T-score at baseline | 0.002 (−0.001;0.006) | −0.004 (−0.010;0.002) | ||
Antiresorptive treatment at baseline, yes | 0.000 (−0.007;0.008) | −0.049 (−0.101;0.002) | ||
Antiresorptive treatment at year 10, yes | 0.004 (−0.002;0.010) | 0.025 (0.008;0.042) | ||
Falls in past month, yes | 0.003 (−0.010;0.015) | 0.018 (−0.007;0.042) | ||
Ever confined to bed (immobilized), yes | 0.000 (−0.010;0.009) | 0.010 (−0.004;0.023) | ||
Ever lost more than 10 pounds, yes | 0.005 (−0.001;0.010) | 0.005 (−0.005;0.015) | ||