Table 5 Model 1: Effects of cognitive impairment (MMSE) measured at baseline on I-ADL level over time estimated by linear mixed model with random effects for intercepts and time ¹

Effect of main variables³

Time

−0.13 (−0.17; −0.09)

<0.001

−0.13 (−0.17; −0.10)

<0.001

Time* Time

0.0007 (0.00007; 0.001)

0.029

0.0006 (0.00001; 0.001)

0.046

MMSE at T1

0.24 (0.21; 0.26)

<0.001

0.07 (0.04; 0.10)

<0.001

MMSE *Time

0.003 (0.002; 0.004)

<0.001

0.003 (0.002; 0.004)

<0.001

Effect of additional variables at T1⁴

Socio –demographic information

Women

0.82 (0.59; 1.04)

<0.001

0.62 (0.43; 0.80)

<0.001

Age (years)

−0.08 (−0.10; −0.06)

<0.001

−0.06 (−0.07; −0.04)

<0.001

Single

0.71 (0.48; 0.95)

<0.001

0.35 (0.16; 0.54)

<0.001

General somatic health

Very poor

−2.33 (−2.75; −1.91)

<0.001

−1.51 (−1.85; −1.17)

<0.001

Poor

−1.72 (−2.03; −1.42)

<0.001

−1.05 (−1.29; −0.80)

<0.001

Fair

−1.03 (−1.32; −0.74)

<0.001

−0.55 (−0.78; −0.32)

<0.001

Good

Reference

Reference

Diagnoses

Dementia

−3.05 (−3.26; −2.84)

<0.001

−1.40 (−1.73; −1.08)

<0.001

MCI

−0.84 (−1.06; −0.62)

<0.001

−0.22 (−0.45; −0.003)

0.047

No

Reference

Reference

Neuropsychiatric sub-syndrome score

Agitation

−0.10 (−0.12; −0.07)

<0.001

0.02 (−0.006; 0.04)

0.155

Psychosis

−0.35 (−0.40; −0.30)

<0.001

−0.16 (−0.20; −0.11)

<0.001

Affective

−0.13 (−0.15; −0.11)

<0.001

−0.04 (−0.06; −0.02)

<0.001

Use of psychotropic medication

Antipsychotics

−1.29 (−1.83; −0.75)

<0.001

−0.49 (−0.91; −0.08)

0.019

Antidepressants

−0.77 (−1.06; −0.49)

<0.001

−0.34 (−0.57; −0.11)

0.003

Anxiolytics

−0.76 (−1.15; −0.38)

<0.001

−0.20 (−0.50; 0.10)

0.183

Sedatives

−0.09 (−0.35; 0.17)

0.509

0.07 (−0.13; 0.27)

0.490

Cognitive enhancers

−2.46 (−2.91; −2.02)

<0.001

−0.62 (−0.99; −0.25)

0.001