Table 3 Numbers of study subjects receiving potentially inappropriate medications for treatment of GAD*
Medication | Potentially Inappropriate | Possibly Appropriate | Total |
|---|---|---|---|
Benzodiazepines | |||
Short-acting | |||
Alprazolam1 | 0 (0.0) | 29 (3.0) | 29 (3.0) |
Lorazepam2 | 50 (5.1) | 21 (2.2) | 71 (7.3) |
Lormetazepam | 14 (1.4) | 0 (0.0) | 14 (1.4) |
Oxazepam3 | 0 (0.0) | 88 (9.0) | 88 (9.0) |
Temazepam4 | 8 (0.8) | 0 (0.0) | 8 (0.8) |
Tetrazepam | 0 (0.0) | 29 (3.0) | 29 (3.0) |
Triazolam5 | 0 (0.0) | 1 (0.1) | 1 (0.1) |
Zolpidem6 | 32 (3.3) | 3 (0.3) | 34 (3.5) |
Any of above | 97 (9.9) | 162 (16.6) | 242 (24.8) |
Long-acting** | |||
Chlordiazepoxide | 6 (0.6) | --- | 6 (0.6) |
Chlorazepate | 11 (1.1) | --- | 11 (1.1) |
Clobazam | 2 (0.2) | --- | 2 (0.2) |
Clonazepam | 3 (0.3) | --- | 3 (0.3) |
Diazepam | 91 (9.3) | --- | 91 (9.3) |
Flunitrazepam | 7 (0.7) | --- | 7 (0.7) |
Flurazepam | 6 (0.6) | --- | 6 (0.6) |
Halazepam | 0 (0.0) | --- | 0 (0.0) |
Medazepam | 5 (0.5) | --- | 5 (0.5) |
Nordazepam | 2 (0.2) | --- | 2 (0.2) |
Prezepam | 0 (0.0) | --- | 0 (0.0) |
Bromazepam | 93 (9.5) | --- | 93 (9.5) |
Nitrazepam | 14 (1.4) | --- | 14 (1.4) |
Midazolam | 0 (0.0) | --- | 0 (0.0) |
Any of above | 225 (23.1) | --- | 225 (23.1) |
Any of above | 298 (30.6) | 162 (16.6) | 426 (43.7) |
Tricyclic antidepressants | |||
Amitriptyline | 52 (5.3) | --- | 52 (5.3) |
Amitriptylinoxide | 0 (0.0) | 3 (0.3) | 3 (0.3) |
Clomipramine | 0 (0.0) | 4 (0.4) | 4 (0.4) |
Dibenzepin | 0 (0.0) | 3 (0.3) | 3 (0.3) |
Desipramine | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Doxepin | 70 (7.2) | --- | 70 (7.2) |
Imipramine | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Maprotiline | 0 (0.0) | 4 (0.4) | 4 (0.4) |
Nortriptyline | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Opipramol | 0 (0.0) | 105 (10.8) | 105 (10.8) |
Trimipramine | 0 (0.0) | 29 (3.0) | 29 (3.0) |
Any of above | 119 (12.2) | 142 (14.6) | 250 (25.6) |
Selective serotonin reuptake inhibitors | |||
Escitalopram | 0 (0.0) | 7 (0.7) | 7 (0.7) |
Citalopram | 0 (0.0) | 40 (4.1) | 40 (4.1) |
Fluoxetine | 11 (1.1) | 0 (0.0) | 11 (1.1) |
Fluvoxamine | 0 (0.0) | 3 (0.3) | 3 (0.3) |
Paroxetine | 0 (0.0) | 16 (1.6) | 16 (1.6) |
Sertraline | 0 (0.0) | 13 (1.3) | 13 (1.3) |
Any of above | 11 (1.1) | 77 (7.9) | 86 (8.8) |
Venlafaxine | 0 (0.0) | 9 (0.9) | 9 (0.9) |
Hydroxyzine | 4 (0.4) | --- | 4 (0.4) |
Buspirone | 0 (0.0) | 5 (0.5) | 5 (0.5) |
Pregabalin | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Trifluoperazine | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Any of above | 392 (40.2) | 345 (35.4) | 607 (62.3) |