Unadjusted regression coefficients | Adjusted regression coefficients | |||
---|---|---|---|---|
Coeff. (95% CI) | p-value | Coeff. (95% CI) | p-value | |
Effect of main variables 1 | ||||
Time | 0.06 (0.02; 0.10) | 0.002 | 0.18 (0.14; 0.22) | <0.001 |
Time* time | 0.001 (-0.001; -0.001) | <0.001 | -0.001 (-0.001; -0.0004) | <0.001 |
CDR sum of boxes (at 4 time points) | 0.48 (0.43; 0.54) | <0.001 | 0.60 (0.52; 0.67) | <0.001 |
Time* CDR sum of boxes | 0.003 (0.001; 0.006) | 0.007 | -0.003 (-0.006; -0.0006) | 0.019 |
Effect of additional variables at baseline 2 | ||||
Length of stay | 0.002 (0.001; 0.002) | <0.001 | 0.001 (0.001; 0.0011) | <0.001 |
Socio –demographic information | ||||
Age (years) | -0.02 (-0.06; 0.02) | 0.312 | -0.04 (-0.08; -0.004) | 0.030 |
Women | -0.33 (-1.03; 0.38) | 0.362 | -0.51 (-1.13; 0.11) | 0.108 |
Single | -0.80 (-1.58; -0.03) | 0.042 | -0.78 (-1.45; -0.11) | 0.023 |
Ten years of education or less | 0.46 (-0.25; 1.17) | 0.206 | 0.45 (-0.14; 1.03) | 0.136 |
Somatic health difficulties | ||||
Co-morbidity index | 0.21 (-0.04; 0.46) | 0.100 | 0.35 (0.15; 0.56) | 0.001 |
No severe vision impairment | 1.65 (0.77; 2.53) | <0.001 | 0.88 (0.14; 1.61) | 0.019 |
No severe hearing impairment | -0.79 (-1.70; 0.13) | 0.091 | -0.16 (-0.92; 0.61) | 0.689 |
Effect of additional variables assessed at 4 time-points 2 | ||||
Degree of neuropsychiatric problems | ||||
Agitation sub-syndrome | 0.04 (0.02; 0.06) | <0.001 | 0.03 (0.003; 0.05) | 0.026 |
Psychosis sub- syndrome | 0.02 (-0.01; 0.06) | 0.173 | ||
Affective sub-syndrome | 0.01 (-0.03; 0.04) | 0.614 | -0.03 (-0.06; 0.01) | 0.166 |
Apathy | 0.20 (0.15; 0.24) | <0.001 | 0.12 (0.08; 0.17) | <0.001 |
Use of psychotropic medication | ||||
Antipsychotics | 0.77 (0.31; 1.23) | 0.001 | 0.41 (-0.03; 0.86) | 0.067 |
Antidepressants | -0.63 (-1.05; -0.20) | 0.004 | -0.40 (-0.80; 0.003) | 0.052 |
Anxiolytics | -0.67 (-1.15; -0.20) | 0.005 | -0.77 (-1.22; -0.32) | 0.001 |
Sedatives | -0.29 (-0.75; 0.17) | 0.213 | ||
Cognitive enhancers | -2.31 (-2.94; -1.67) | <0.001 | -1.72 (-2.33; -1.11) | <0.001 |