Figure 3
From: PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals
PML-NBs depending on individuals’ age. (A) PML-NBs per cell in patients with breast cancer and rectal cancer as well as healthy individuals. (B) Mean number of PML-NBs per cell without irradiation, after 0.5 Gy and 30 minutes repair time, after 2 Gy and 24 hours repair time and three days after one week of radiochemotherapy. (C) PML-NBs per cell dependent on age. Patients are represented by squares and the healthy individuals by circles. A linear fit was used. Patients are depicted by the solid line and healthy individuals by the dashed line. (D) The mean PML-NBs per cell of cancer patients and healthy individuals within groups comprising ten years of age are represented by squares. (E) Pre-existing γH2AX foci per cell in dependence of age in healthy individuals (squares) and patients (circles). (F) The mean γH2AX foci per cell of patients within groups comprising 10 years of age are represented by squares. There is a significant (p = 0.01) increase in γH2AX per cell between the group comprising 50 to 60 year-old study participants and the group including 60 to 70-year-old individuals. (G) Patients PML-NBs per cell divided into age groups comprising ten years of age. The solid line depicts the pre-existing PML-NBs per cell and the dashed line PML-NBs three days after one week of radiochemotherapy. (H) Dmean and (I) Edep in dependence of age comprised in ten-year periods. Error bars depict the standard deviation of the mean.