Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly

BMC Geriatrics

Table 3 Correlation between NT-proBNP Levels and Echocardiographic Parameters

	Tertiles of NT-proBNP^*				Adjusted B (95% CI)
	1 (n= 26)	2 (n= 27)	3 (n= 27)	Pfor trend	Model 1**, adjusted R²= 0.19 Model 2^£, adjusted R²= 0.35	P
LV dimensions and systolic function
LV EDD (mm)	42 (39 - 51)	47 (43 - 54)	51 (45 - 56)	0.003	-0.042 (-0.088 - 0.005)	0.081
LV ESD (mm)	27 (22 - 31)	28 (27 - 33)	32 (29 - 37)	0.002	0.034 (-0.030 - 0.099)	0.29
LV Ejection fraction (%)	69 (60 - 79)	67 (61 - 72)	67 (53 - 74)	0.24	0.006 (-0.017 - 0.030)	0.59
LV Mass index (g/m²)
Men	213 (182 - 287)	236 (177 - 260)	268 (209 - 372)	0.068	0.003 (0.000 - 0.005)	0.045
Women	160 (142 - 190)	212 (169 - 242)	213 (160 - 260)	0.008
Left ventricular diastolic function
E/A	0.61 (0.51 - 0.70)	0.72 (0.61 - 0.78)	0.70 (0.56 - 1.1)	0.016	0.45 (0.026 - 0.87)	0.038
Left atrial volume (ml)	30.1 (22.1 - 40.0)	43.6 (25.6 - 55.3)	50.3 (33.8 - 73.6)	0.002	0.001 (-0.003 - 0.004)	0.67
Significant heart valvular disease
Mitral regurgitation ≥ moderate	4 (11%)	18 (47%)	16 (42%)	0.003	-0.046 (-0.14 - 0.045)^$	0.32
Aortic regurgitation ≥ moderate	3 (13%)	8 (35%)	12 (52%)	0.014	0.11 (0.002 - 0.21)^$	0.046
Any aortic stenosis	7 (50%)	3 (21%)	4 (29%)	0.25	-0.008 (-0.022 - 0.005)^$	0.23
Estimated PAP (mmHg)	33 (26 - 36)	33 (29 - 37)	37 (33 - 40)	0.015	0.008 (-0.020 - 0.035)^£	0.56

Abbreviations: EDD, end-diastolic diameter; ESD, end-systolic diameter; LV, left ventricular; PAP, pulmonary artery pressure.
*Echocardiographic parameters (median (IQR)) compared between gender-specific tertiles of NT-proBNP using the Jonckheere-Terpstra test (continuous variables) or the Chi-Square test with linear-by-linear association (proportions). Median values of NT-proBNP levels were 143.2 pg/mL (IQR 103.3-220.7 pg/mL) in the first tertile, 380.6 pg/mL (IQR 326.2-499.4 pg/mL) in the second tertile and 1324.0 pg/mL (IQR 762.4-2832.0 pg/mL) in the third tertile.
** Linear regression analysis with LogNT-proBNP as dependent variable and all echocardiographic measurements (except estimated PAP) as independent variables, adjusted for gender, BMI, renal function, anemia and medications for heart failure (n = 56).
^$ In the linear regression analysis the degree of mitral and aortic regurgitation were expressed as ordinal variables (1 to 4) and aortic stenosis was expressed as a continuous variable using the aortic valve peak gradient.
^£ Linear regression analysis with LogNT-proBNP as dependent variable and all echocardiographic measurements AND estimated PAP as independent variables, adjusted for gender, BMI, renal function, anemia and medications for heart failure (n = 37).

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