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Neurology, stroke and cognition

Section edited by Pieter Jelle Visser

This section considers manuscripts on all neurological topics. Including: Alzheimer’s, cognition, stroke, dementia, wandering behaviours.

Page 1 of 3

  1. Content type: Research article

    Dementia is a syndrome, with a wide range of symptoms. It is important to have a timely diagnosis during the disease course to reduce the risk of medication errors, enable future care planning for the patient ...

    Authors: Connie Lethin, Ingalill Rahm Hallberg, Anna Renom Guiteras, Hilde Verbeek, Kai Saks, Minna Stolt, Adelaida Zabalegui, Maria Soto-Martin and Christer Nilsson

    Citation: BMC Geriatrics 2019 19:172

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  2. Content type: Case report

    Dementia with Lewy bodies (DLB) is still underdiagnosed or mistaken for other types of neurodegenerative diseases. Biomarkers such as 18-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) can be helpful.

    Authors: Astrid Melani Suantio, Hian Liang Huang, Cecilia Sze Nga Kwok, Darren Cheng Han Teo and Minh Ha Nguyen

    Citation: BMC Geriatrics 2019 19:150

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  3. Content type: Research article

    Smartphone use has become an increasingly pervasive part of our daily lives, and as a portable media device, smartphones provide good support for cognitive training during aging. However, little is known about...

    Authors: Manqiong Yuan, Jia Chen, Zi Zhou, Jiahui Yin, Jielong Wu, Mingliang Luo, Lixia Wang and Ya Fang

    Citation: BMC Geriatrics 2019 19:140

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  4. Content type: Research article

    The main objective of this research was to evaluate the acceptance of technology based on a wearable lifelogging camera in a sample of older adults diagnosed with mild cognitive impairment (MCI).

    Authors: Olga Gelonch, Mireia Ribera, Núria Codern-Bové, Sílvia Ramos, Maria Quintana, Gloria Chico, Noemí Cerulla, Paula Lafarga, Petia Radeva and Maite Garolera

    Citation: BMC Geriatrics 2019 19:110

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  5. Content type: Study protocol

    Previous observational studies and clinical trials have shown that cholinesterase inhibitors (with or without memantine) provide benefit for patients with mild-to-moderate Alzheimer’s disease. However, the imp...

    Authors: Aina Soler, Guillem Amer, Alicia Leiva, Joana Ripoll, María Angeles Llorente, Alfonso Leiva, Joana Maria Taltavull, Rosa Molina and Joan Llobera

    Citation: BMC Geriatrics 2019 19:101

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  6. Content type: Research article

    The elderly, and especially those with an immuno-compromised status, are vulnerable to infectious diseases. The purpose of this study was to examine the clinical characteristics and therapeutic outcomes of cry...

    Authors: Wan-Chen Tsai, Chia-Yi Lien, Jun-Jun Lee, Wen-Chiu Hsiao, Chi-Ren Huang, Nai-Wen Tsai, Chiung-Chih Chang, Cheng-Hsien Lu and Wen-Neng Chang

    Citation: BMC Geriatrics 2019 19:91

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  7. Content type: Research article

    Older adults often suffer from age- and behavior-related brain changes affecting neuronal functioning and, therefore, cognitive and motor functions. The improvement of these functions might decrease falls and ...

    Authors: Alexandra Schättin, Corinne Baier, Domenique Mai, Verena Klamroth-Marganska, Isabelle Herter-Aeberli and Eling D. de Bruin

    Citation: BMC Geriatrics 2019 19:81

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  8. Content type: Research article

    Visual rating scales are still the most popular tools in assessing atrophy degrees of whole brain and lobes. However, the false negative rate of the previous cutoff score of visual rating scales was relatively...

    Authors: Mingqing Wei, Jing Shi, Jingnian Ni, Xuekai Zhang, Ting Li, Zilong Chen, Mengling Zhou, Liping Zhang, Zhongjian Tan, Yongyan Wang and Jinzhou Tian

    Citation: BMC Geriatrics 2019 19:59

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  9. Content type: Research article

    Stroke incidence has declined during the past decades. Yet, there is a concern that an ageing population together with improved survival after stroke will result in a raised proportion of the population who ha...

    Authors: Karin Modig, Mats Talbäck, Louise Ziegler and Anders Ahlbom

    Citation: BMC Geriatrics 2019 19:31

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  10. Content type: Research article

    Alterations in autonomic nervous system (ANS) activity might be involved in the pathophysiology of delirium. The aim was to explore autonomic cardiovascular control in older patients with and without delirium.

    Authors: Bjørn Erik Neerland, Torgeir Bruun Wyller and Vegard Bruun Bratholm Wyller

    Citation: BMC Geriatrics 2019 19:23

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  11. Content type: Research article

    Dementia patients often show neuropsychiatric symptoms, known as behavioral and psychological symptoms of dementia (BPSD). These are a common motive for medical consultations, hospitalizations, and nursing hom...

    Authors: Mireia Massot Mesquida, Montserrat Tristany Casas, Alicia Franzi Sisó, Isabel García Muñoz, Óscar Hernández Vian and Pere Torán Monserrat

    Citation: BMC Geriatrics 2019 19:7

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  12. Content type: Research article

    Aging and rural-urban disparities are two major social problems in today’s ever-developing China. Much of the existing literature has supported a negative association between adverse community setting with the...

    Authors: Yuanxi Xiang, Hossein Zare, Cuiling Guan and Darrell Gaskin

    Citation: BMC Geriatrics 2018 18:323

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  13. Content type: Study protocol

    The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated prote...

    Authors: Nienke Legdeur, Maryam Badissi, Stephen F. Carter, Sophie de Crom, Aleid van de Kreeke, Ralph Vreeswijk, Marijke C. Trappenburg, Mardien L. Oudega, Huiberdina L. Koek, Jos P. van Campen, Carolina J. P. W. Keijsers, Chinenye Amadi, Rainer Hinz, Mark F. Gordon, Gerald Novak, Jana Podhorna…

    Citation: BMC Geriatrics 2018 18:289

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  14. Content type: Research article

    Patients with delirium have increased risk of death, dementia and institutionalization, and prognosis differs between delirium motor subtypes. A few studies have identified associations between environmental f...

    Authors: Sigurd Evensen, Ingvild Saltvedt, Stian Lydersen, Torgeir Bruun Wyller, Kristin Taraldsen and Olav Sletvold

    Citation: BMC Geriatrics 2018 18:282

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  15. Content type: Study protocol

    One of the crucial challenges for the future of therapeutic approaches to Alzheimer’s disease (AD) is to target the main pathological processes responsible for disability and dependency. However, a progressive...

    Authors: Nawele Boublay, Denis Fédérico, Alain Pesce, Marc Verny, Frédéric Blanc, Marc Paccalin, Thomas Desmidt, Pierre Grosmaître, Olivier Moreaud, Solveig Relland, Estelle Bravant, Romain Bouet and Pierre Krolak-Salmon

    Citation: BMC Geriatrics 2018 18:280

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  16. Content type: Research article

    Dementia and physical morbidity are primary reasons for nursing home admission globally. However, data on physical morbidity in nursing home residents with and without dementia are scarce. The first aim of the...

    Authors: Live Bredholt Jørgensen, Berit Marie Thorleifsson, Geir Selbæk, Jūratė Šaltytė Benth and Anne-Sofie Helvik

    Citation: BMC Geriatrics 2018 18:254

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  17. Content type: Research article

    The objective of this study was to examine patient characteristics and health care resource utilization (HCRU) in the 36 months prior to a confirmatory diagnosis of Alzheimer’s disease (AD) compared to a match...

    Authors: Radhika Nair, Virginia S. Haynes, Mir Siadaty, Nick C. Patel, Adam S. Fleisher, Derek Van Amerongen, Michael M. Witte, AnnCatherine M. Downing, Leslie Ann Hazel Fernandez, Vishal Saundankar and Daniel E. Ball

    Citation: BMC Geriatrics 2018 18:243

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  18. Content type: Research Article

    The conventional scores of the neuropsychological batteries are not fully optimized for diagnosing dementia despite their variety and abundance of information. To achieve low-cost high-accuracy diagnose perfor...

    Authors: Hyun-Soo Choi, Jin Yeong Choe, Hanjoo Kim, Ji Won Han, Yeon Kyung Chi, Kayoung Kim, Jongwoo Hong, Taehyun Kim, Tae Hui Kim, Sungroh Yoon and Ki Woong Kim

    Citation: BMC Geriatrics 2018 18:234

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  19. Content type: Study protocol

    Delirium is a common and serious clinical syndrome which is often missed in routine clinical care. The core cognitive feature is inattention. We developed a novel bedside neuropsychological test for assessing ...

    Authors: Lisa-Marie Rutter, Eva Nouzova, David J. Stott, Christopher J. Weir, Valentina Assi, Jennifer H. Barnett, Caoimhe Clarke, Nikki Duncan, Jonathan Evans, Samantha Green, Kirsty Hendry, Meigan McGinlay, Jenny McKeever, Duncan G. Middleton, Stuart Parks, Robert Shaw…

    Citation: BMC Geriatrics 2018 18:217

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  20. Content type: Research Article

    Driving is related to social participation; therefore older drivers may be reluctant to cease driving. Continuation of driving has also been reported in a large proportion of patients with cognitive impairment...

    Authors: Dafne Piersma, Anselm B. M. Fuermaier, Dick De Waard, Ragnhild J. Davidse, Jolieke De Groot, Michelle J. A. Doumen, Rudolf W. H. M. Ponds, Peter P. De Deyn, Wiebo H. Brouwer and Oliver Tucha

    Citation: BMC Geriatrics 2018 18:216

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  21. Content type: Research article

    Individuals with mild cognitive impairment (MCI) are at heightened risk of developing dementia. Rapid advances in computing technology have enabled researchers to conduct cognitive training and rehabilitation ...

    Authors: Shaoqing Ge, Zheng Zhu, Bei Wu and Eleanor S. McConnell

    Citation: BMC Geriatrics 2018 18:213

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  22. Content type: Research article

    Cognition is a key factor in the regulation of normal walking and dual-task gait assessment is an accepted method to evaluate the relationship. The objective of this study was to create a framework for task co...

    Authors: Susan W. Hunter, Alison Divine, Courtney Frengopoulos and Manuel Montero Odasso

    Citation: BMC Geriatrics 2018 18:202

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  23. Content type: Research article

    An association between handgrip strength, hand dexterity and global cognition is suggested; however, it is unclear whether both hand motor functions are associated with executive function, which is important f...

    Authors: Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Naoko Sakuma, Hiroyuki Suzuki, Masashi Yasunaga, Susumu Ogawa, Toru Takebayashi and Yoshinori Fujiwara

    Citation: BMC Geriatrics 2018 18:192

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    The Correction to this article has been published in BMC Geriatrics 2018 18:210

  24. Content type: Research article

    Risk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55–85 yea...

    Authors: N. Legdeur, M. W. Heymans, H. C. Comijs, M. Huisman, A. B. Maier and P. J. Visser

    Citation: BMC Geriatrics 2018 18:187

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  25. Content type: Research article

    The risk-benefit relationship of memantine treatment for Alzheimer’s disease (AD) remains unclear. In addition, variability between the results of clinical trials has been observed. The aim of this study was t...

    Authors: Lídia Blanco-Silvente, Dolors Capellà, Josep Garre-Olmo, Joan Vilalta-Franch and Xavier Castells

    Citation: BMC Geriatrics 2018 18:168

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  26. Content type: Study protocol

    Late-life cognitive decline, caused by progressive neuronal loss leading to brain atrophy years before symptoms are detected, is expected to double in Canada over the next two decades. Cognitive impairment in ...

    Authors: Sana Tariq, Christopher D. d’Esterre, Tolulope T. Sajobi, Eric E. Smith, Richard Stewart Longman, Richard Frayne, Shelagh B. Coutts, Nils D. Forkert and Philip A. Barber

    Citation: BMC Geriatrics 2018 18:163

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  27. Content type: Research article

    The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) is widely used as a complementary screening tool for dementia. However, there are few studies concerning the efficacy of the IQCODE for ...

    Authors: Yunlong Ding, Jiali Niu, Yanrong Zhang, Wenpeng Liu, Yan Zhou, Can Wei and Yan Liu

    Citation: BMC Geriatrics 2018 18:146

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  28. Content type: Research article

    Alzheimer’s disease (AD) dementia, a progressive neurodegenerative disease, exerts significant burden upon patients, caregivers, and healthcare systems globally. The current study investigated the associations...

    Authors: William Montgomery, Amir Goren, Kristin Kahle-Wrobleski, Tomomi Nakamura and Kaname Ueda

    Citation: BMC Geriatrics 2018 18:141

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  29. Content type: Research article

    Community health professionals play a significant role in dementia care. However, little is known about community health professionals’ capacity in dementia care, especially in low and middle-income countries....

    Authors: Yao Wang, Lily Dongxia Xiao, Yang Luo, Shui-Yuan Xiao, Craig Whitehead and Owen Davies

    Citation: BMC Geriatrics 2018 18:122

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  30. Content type: Research article

    Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of thi...

    Authors: Rannveig Sakshaug Eldholm, Karin Persson, Maria Lage Barca, Anne-Brita Knapskog, Lena Cavallin, Knut Engedal, Geir Selbaek, Eva Skovlund and Ingvild Saltvedt

    Citation: BMC Geriatrics 2018 18:120

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  31. Content type: Study protocol

    There are effective non-pharmacological treatment programs that reduce functional disability and changed behaviours in people with dementia. However, these programs (such as the Care of People with dementia in...

    Authors: Lindy Clemson, Kate Laver, Yun-Hee Jeon, Tracy A Comans, Justin Scanlan, Miia Rahja, Jennifer Culph, Lee-Fay Low, Sally Day, Monica Cations, Maria Crotty, Susan Kurrle, Catherine Piersol and Laura N. Gitlin

    Citation: BMC Geriatrics 2018 18:108

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  32. Content type: Research Article

    Self-rated health predicts health outcomes independently of levels of disability or mood. Little is known about what influences the subjective health experience of stroke survivors. Our aim was to investigate ...

    Authors: N. Mavaddat, E. Sadler, L. Lim, K. Williams, E. Warburton, A. L. Kinmonth, J. Mant, J. Burt and C. McKevitt

    Citation: BMC Geriatrics 2018 18:81

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  33. Content type: Research article

    Many older adults have low levels of health literacy which affects their ability to participate optimally in healthcare. It is unclear how cognitive decline contributes to health literacy. To study this, longi...

    Authors: Bas Geboers, Ellen Uiters, Sijmen A. Reijneveld, Carel J. M. Jansen, Josué Almansa, Astrid C. J. Nooyens, W. M. Monique Verschuren, Andrea F. de Winter and H. Susan J. Picavet

    Citation: BMC Geriatrics 2018 18:77

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  34. Content type: Research Article

    Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical ...

    Authors: Iris Zahirovic, Gustav Torisson, Carina Wattmo and Elisabet Londos

    Citation: BMC Geriatrics 2018 18:50

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  35. Content type: Research Article

    It has been suggested that tooth loss in later life might increase dementia incidence. The objective of this analysis is to systematically review the current evidence on the relationship between the number of ...

    Authors: Bumjo Oh, Dong-Hun Han, Kyu-Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis and Ji Won Yoo

    Citation: BMC Geriatrics 2018 18:48

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  36. Content type: Research article

    Cognitive impairment places older adults at high risk of functional disability in their daily-life activities, and thus affecting their quality of life. This study aimed to examine the effects of Tai Chi on ge...

    Authors: Mei-yi Siu and Diana T. F. Lee

    Citation: BMC Geriatrics 2018 18:37

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  37. Content type: Research Article

    Identifying how persons with dementia experience lived space is important for enabling supportive living environments and creating communities that compensate for the fading capabilities of these persons. Seve...

    Authors: Linn Hege Førsund, Ellen Karine Grov, Anne-Sofie Helvik, Lene Kristine Juvet, Kirsti Skovdahl and Siren Eriksen

    Citation: BMC Geriatrics 2018 18:33

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  38. Content type: Study protocol

    Given the world’s aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitiv...

    Authors: Lisanne F. ten Brinke, John R. Best, Rachel A. Crockett and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2018 18:31

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  39. Content type: Research article

    Delirium increases the risk of mortality during an acute hospital admission. Full syndromal delirium (FSD) is associated with greatest risk and subsyndromal delirium (SSD) is associated with intermediate risk,...

    Authors: R. A. Diwell, D.H. Davis, V. Vickerstaff and E. L. Sampson

    Citation: BMC Geriatrics 2018 18:24

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  40. Content type: Research article

    Medications are frequently reported as both predisposing factors and inducers of delirium. This review evaluated the available evidence and determined the magnitude of risk of postoperative delirium associated...

    Authors: Gizat M. Kassie, Tuan A. Nguyen, Lisa M. Kalisch Ellett, Nicole L. Pratt and Elizabeth E. Roughead

    Citation: BMC Geriatrics 2017 17:298

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  41. Content type: Research Article

    Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis rema...

    Authors: Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao and Katsunori Kondo

    Citation: BMC Geriatrics 2017 17:297

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  42. Content type: Research Article

    Reduced level of arousal is commonly observed in medical admissions and may predict in-hospital mortality. Delirium and reduced level of arousal are closely related. We systematically reviewed and conducted a ...

    Authors: Amy Todd, Samantha Blackley, Jennifer K. Burton, David J. Stott, E. Wesley Ely, Zoë Tieges, Alasdair M. J. MacLullich and Susan D. Shenkin

    Citation: BMC Geriatrics 2017 17:283

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  43. Content type: Research Article

    Anxiety and depression are common in Parkinson disease and both are important determinants of quality of life in patients. Several risk factors are identified but few research have investigated general and Par...

    Authors: Shi-Shuang Cui, Juan-Juan Du, Rao Fu, Yi-Qi Lin, Pei Huang, Ya-Chao He, Chao Gao, Hua-Long Wang and Sheng-Di Chen

    Citation: BMC Geriatrics 2017 17:270

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  44. Content type: Research Article

    Dementia imposes a high burden of disease worldwide. Recent epidemiological studies in European community samples are scarce. In Portugal, community prevalence data is very limited. The 10/66 Dementia Research...

    Authors: Manuel Gonçalves-Pereira, Ana Cardoso, Ana Verdelho, Joaquim Alves da Silva, Manuel Caldas de Almeida, Alexandra Fernandes, Cátia Raminhos, Cleusa P. Ferri, A. Matthew Prina, Martin Prince and Miguel Xavier

    Citation: BMC Geriatrics 2017 17:261

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  45. Content type: Research Article

    Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated the relationships between cognitive function and body composition among community-...

    Authors: Hye-Mi Noh, Sohee Oh, Hong Ji Song, Eun Young Lee, Jin-Young Jeong, Ohk-Hyun Ryu, Kyung-Soon Hong and Dong-Hyun Kim

    Citation: BMC Geriatrics 2017 17:259

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  46. Content type: Research Article

    The Doloplus-2 is a pain assessment scale for assessing pain in older adults with cognitive impairment. It is used in clinical practice and research. However, evidence for its measurement properties, feasibili...

    Authors: Hanne Marie Rostad, Inger Utne, Ellen Karine Grov, Martine Puts and Liv Halvorsrud

    Citation: BMC Geriatrics 2017 17:257

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  47. Content type: Research article

    Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer’s disease. Trp may serve as a potential biomarker for monitoring dis...

    Authors: Yusuke Adachi, Yoshiki Shimodaira, Hidehiro Nakamura, Akira Imaizumi, Maiko Mori, Yoko Kageyama, Yasushi Noguchi, Asuka Seki, Yuki Okabe, Yuko Miyake, Kaori Ono and Shu Kumagai

    Citation: BMC Geriatrics 2017 17:239

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