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Table 5 Analysis of Covariance between DBI, DBA, DBS and Grip Strength, Reciprocal TUG and BI

From: Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study

 

DBI > 0

DBA > 0

DBS > 0

B (95% CI)

p

n

B (95% CI)

p

n

B (95% CI)

p

n

Grip strength (females)

 n = 251

−0.937 (−3.083; 1.209)

0.391

198

−0.252 (−2.122; 1.618)

0.791

169

−2.048 (−3.784; − 0.313)

0.021*

125

 n = 209*

0.998 (−1.240; 3.235)

0.380

162

1.224 (−0.720; 3.168)

0.216

139

−0.557 (−2.418; 1.303)

0.555

108

Grip strength (males)

 n = 186

−2.062 (−5.418; 1.295)

0.227

131

−1.358 (−4.566; 1.850)

0.405

120

1.126 (−1.992; 4.244)

0.477

77

 n = 142*

0.465 (−3.470; 4.400)

0.816

102

1.430 (−2.251; 5.111)

0.444

94

3.064 (−0.512; 6.641)

0.092

60

Reciprocal TUG

 n = 468

−0.008 (− 0.014; − 0.002)

0.010*

359

−0.007 (− 0.013; − 0.001)

0.016*

316

−0.009 (− 0.014; − 0.004)

0.001*

215

 n = 383*

0.002 (− 0.004; 0.009)

0.517

295

0.002 (− 0.004; 0.008)

0.512

261

− 0.003 (− 0.009; 0.002)

0.241

184

Barthel Index

 n = 635

−3.561 (−4.705; −2.417)

< 0.001*

500

−2.467 (− 3.487; −1.447)

< 0.001*

436

− 3.275 (− 4.204; − 2.346)

< 0.001*

315

 n = 464*

− 1.060 (− 2.285; 0.165)

0.090

369

−0.782 (− 1.837; 0.273)

0.146

323

−1.438 (− 2.435; − 0.440)

0.005*

238

  1. *For each end-point the first row represents unadjusted model and second row adjusted model for age, level of ID, history of falls, Functional Comorbidity Index, number of non-DBI medicines. Grip strength is also adjusted for Down syndrome. TUG and Barthel Index are adjusted for gender. B, parameter estimate; CI, confidence interval; DBI, Drug Burden Index; DBA, anticholinergic component of Drug Burden Index; DBS, sedative component of Drug Burden Index; p, significance; n, number exposed to anticholinergic and/or sedative drugs. n first row, number of subjects completing each test; n second row represents available data on subjects after controlling for confounders
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BMC Geriatrics

ISSN: 1471-2318

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