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Table 4 Sensitivity, specificity and positive predictive values (PPV) at different prevalence rates of optimal cut off ACE-III, HDS-R, and MMSE scores for identifying MCI and dementia (Values in parentheses represent the respective negative predictive value)

From: Validation of Addenbrooke’s cognitive examination III for detecting mild cognitive impairment and dementia in Japan

TEST

CUT-OFF

MCI

PPV at different prevalence rates

 

SCORE

SENSITIVITY

SPECIFICITY

5%

10%

20%

40%

ACE-III

88/89

0.77

0.92

0.35 (0.99)

0.52 (0.97)

0.72 (0.94)

0.87 (0.86)

HDS-R

24/25

0.57

0.89

0.22 (0.98)

0.37 (0.95)

0.57 (0.89)

0.78 (0.76)

MMSE

26/27

0.61

0.86

0.19 (0.98)

0.33 (0.95)

0.52 (0.90)

0.75 (0.77)

TEST

CUT-OFF

DEMENTIA

PPV at different prevalence rates

 

SCORE

SENSITIVITY

SPECIFICITY

5%

10%

20%

40%

ACE-III

75/76

0.82

0.90

0.30 (0.99)

0.48 (0.98)

0.67 (0.95)

0.85 (0.88)

HDS-R

20/21

0.67

0.89

0.24 (0.98)

0.39 (0.96)

0.59 (0.91)

0.80 (0.80)

MMSE

23/24

0.64

0.87

0.21 (0.98)

0.36 (0.96)

0.55 (0.91)

0.77 (0.78)

  1. ACE-III Addenbrooke’s Cognitive Examination-III, HDS-R Hasegawa Dementia Scale-revised, MMSE Mini-mental State Examination