Influence of activity space on the association between neighborhood characteristics and dementia risk: results from the 3-City study cohort

Table 3 Association between advantaged neighborhood characteristics and risk of dementia, according to activity space

Advantaged neighborhood characteristics		All-type dementia (n = 789)	Univariate model		Multivariate model^a
Advantaged neighborhood characteristics		n	HR (95% IC)	p	HR (95% IC)	p
Median household net taxable income	No limited activity space
	T1 (< 15,487)	210	1	–	1	–
	T2 (15487–18,091)	202	1.00 (0.81–1.24)	0.99	1.06 (0.86–1.31)	0.58
	T3 (> 18,091)	200	0.92 (0.76–1.10)	0.34	1.01 (0.83–1.24)	0.91
	Global p-value			0.55		0.83
	Limited activity space
	T1 (< 15,487)	81	1	–	1	–
	T2 (15487–18,091)	53	0.68 (0.49–0.94)	0.02	0.67 (0.48–0.94)	0.02
	T3 (> 18,091)	43	0.64 (0.46–0.90)	0.009	0.68 (0.46–1.00)	0.05
	Global p-value			0.008		0.03
Proportion of people aged 60 years or over	No limited activity space
	T1 (< 20.0)	214	1	–	1	–
	T2 (20.0–24.7)	190	0.89 (0.73–1.09)	0.26	0.93 (0.77–1.14)	0.49
	T3 (> 24.7)	208	0.97 (0.79–1.19)	0.78	0.97 (0.80–1.19)	0.78
	Global p-value			0.48		0.78
	Limited activity space
	T1 (< 20.0)	79	1	–	1	–
	T2 (20.0–24.7)	42	0.61 (0.44–0.85)	0.003	0.65 (0.47–0.91)	0.01
	T3 (> 24.7)	56	0.68 (0.49–0.95)	0.02	0.71 (0.51–0.99)	0.04
	Global p-value			0.004		0.02

^aMarginal Cox model adjusted for sex, study center, education level, income, occupational category, APOEε4 carrier status, diabetes, history of cardiovascular diseases, depressive symptoms and disability (IADL « budget, medication, phone »)
Note: People with limited activity space = people who have need to help to go shopping, or if they are unable to move without being accompanied, or if people are confined at home or at their neighborhood

ISSN: 1471-2318