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Table 2 Descriptive statistics of the plasma immune markers

From: Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons

Immune markers

Patients, N = 64

Controls, N = 18

 

Name

Signalling

Median (Q1, Q3), pg /ml

Median (Q1, Q3), pg /ml

P-valuef

IL-1β

Pro-infl.

1.4 (1.1; 2.0)a

0.5 (0.3; 0.6)e

< 0.001

IL-6

Pro-infl.

6.0 (4.0; 8.0)

2.0 (0.9; 2.3)e

0.001

TNF

Pro-infl.

25 (14; 38)

10 (3; 13)e

< 0.001

IL-12

Pro-infl.

9.0 (6.0; 14.8)

0.2 (0.0; 7.5)e

0.030

IL-17

Pro-infl.

13 (4; 27)

0.0 (0.0; 0.0)e

< 0.001

IFN-γ

Pro-infl.

46 (22; 77)

25 (6; 39)

0.067

PDGFBB

Pro-infl.

17 (7; 37)

2.0 (0.0; 4.8)e

0.003

IL-8

Pro-infl.

10 (8; 13)

5.0 (3.8; 7.0)

< 0.001

Eotaxin

Pro-infl.

60 (47; 84)

30 (25; 43)

0.001

IP-10

Pro-infl.

574 (424; 732)

725 (577; 1000)

0.047

MCP-1

Pro-infl.

20 (17; 26)

12 (9; 14)

< 0.001

MIP-1α

Pro-infl.

3.0 (2.0; 4.0)

2.0 (0.9; 3.0)e

0.052

MIP-1β

Pro-infl.

54 (46; 65)

42 (35; 52)

0.022

RANTES

Pro-infl.

1116 (633; 2711)

571 (347; 850)

0.016

IL-1ra

Anti-infl.

67 (42; 103)

18 (0; 29)e

0.005

IL-10

Anti-infl.

0.0 (0.0; 1.1)c

0.0 (0.0; 0.6)e

0.839

IL-2

Adaptive

5.0 (2.3; 8.0)

0.1 (0.0; 2.3)e

0.001

IL-4

Adaptive

2.0 (1.0; 2.0)

1.0 (1.8; 1.0)

0.208

IL-5

Adaptive

1.2 (1.0; 1.5)b

0.9 (0.8; 1.1)e

< 0.005

IL-7

Adaptive

6.0 (4.3; 7.8)

1.3 (0.1; 2.3)e

< 0.001

IL-9

Adaptive

12 (8; 15)

3.5 (0.4; 8.3)e

0.003

IL-13

Adaptive

4.5 (3.0; 8.0)

2.0 (1.3; 3.0)e

0.002

IL-15

Adaptive

2.5 (0.0; 4.8)d

0.0 (0.0; 0.0)e

< 0.001

GMCSF

Trophic

13 (9; 18)

6.0 (0.7; 10.0)

< 0.001

GCSF

Trophic

25. (16; 35)

0.0 (0.0; 12.3)e

< 0.001

bFGF

Trophic

26 (15; 36)

0.0 (0.0; 15.5)e

0.001

VEGF

Trophic

15 (9; 23)

0.0 (0.0; 1.5)e

< 0.001

  1. Abbreviations: Anti-infl. Anti-inflammatory, bFGF basic fibroblast growth factor, G-CSF granulocyte-colony stimulating factor, GM-CSF granulocyte macrophage colony stimulating factor, IFN interferon, IL interleukin, IP-10 interferon-inducible protein, MCP-1 monocyte chemotactic protein, MIP macrophage inflammatory protein, ml millilitre, N number, PDGF-BB platelet derived growth factor-BB, pg picogram, Pro-infl. Pro-inflammatory, Q quartile, RANTES regulated upon activation T cell expressed and secreted, TNF tumour necrosis factor, VEGF vascular endothelial growth factor
  2. a The concentration values were extrapolated beyond standard range in 49 cases.
  3. b The concentration values were extrapolated beyond standard range in 50 cases.
  4. c The concentration values were extrapolated beyond standard range in 23 cases and the concentration values were out of range in 35 cases.
  5. d The concentration values were extrapolated beyond standard range in three cases and the concentration value were out of range in 22 cases.
  6. e The concentration values were out of range or extrapolated beyond standard range in more than 20% of the cases.
  7. f Independent samples median test.
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BMC Geriatrics

ISSN: 1471-2318

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