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Table 4 Multivariate odds ratios for estimated glomerular filtration rate < 60 mL/min/1.73 m2 or albuminuria by age groups

From: Diabetic kidney disease in the elderly: prevalence and clinical correlates

 

Overall

p

< 65 years

p

65–75 years

p

> 75 years

p

Model for eGFR < 60 mL/min/1.73 m 2

 Male sex

0.85 (0.82–0.88)

< 0.001

0.83 (0.76–0.90)

< 0.001

0.84 (0.80–0.88)

< 0.001

0.86 (0.82–0.91)

< 0.001

 Age (×5 years)

1.81 (1.79–1.83)

< 0.001

1.75 (1.67–1.82)

< 0.001

1.90 (1.82–1.99)

< 0.001

1.77 (1.72–1.83)

< 0.001

 BMI (× 5 Kg/m2)

1.19 (1.17–1.21)

< 0.001

1.13 (1.09–1.17)

< 0.001

1.18 (1.15–1.21)

< 0.001

1.23 (1.20–1.27)

< 0.001

 Albuminuria

2.14 (2.06–2.22)

< 0.001

2.90 (2.66–3.17)

< 0.001

2.22 (2.10–2.35)

< 0.001

1.78 (1.68–1.88)

< 0.001

 HbA1c (×1%)

1.00 (0.99–1.02)

0.839

1.00 (0.97–1.03)

0.979

1.01 (0.99–1.03)

0.421

1.00 (0.98–1.02)

0.976

 Triglycerides ≥150 mg/dl

1.69 (1.63–1.76)

< 0.001

1.85 (1.70–2.02)

< 0.001

1.73 (1.64–1.83)

< 0.001

1.58 (1.49–1.67)

< 0.001

 HDL < 40/< 50 mg/dL (Male/Female)

1.41 (1.36–1.46)

< 0.001

1.34 (1.23–1.46)

< 0.001

1.39 (1.32–1.47)

< 0.001

1.48 (1.40–1.56)

< 0.001

 LDL ≥100 mg/dL

0.88 (0.86–0.91)

< 0.001

0.80 (0.74–0.87)

< 0.001

0.90 (0.85–0.94)

< 0.001

0.91 (0.87–0.96)

< 0.001

 Blood Pressure ≥ 140/85 mmHg

0.87 (0.84–0.90)

< 0.001

1.00 (0.92–1.09)

0.969

0.86 (0.82–0.91)

< 0.001

0.84 (0.79–0.88)

< 0.001

 Smokinga

0.79 (0.74–0.84)

< 0.001

0.73 (0.64–0.83)

< 0.001

0.81 (0.73–0.90)

< 0.001

0.82 (0.71–0.94)

0.004

Model for Albuminuria

 Male sex

2.09 (2.02–2.15)

< 0.001

1.94 (1.83–2.05)

< 0.001

2.30 (2.18–2.42)

< 0.001

2.05 (1.93–2.17)

< 0.001

 Age (×5 years)

1.07 (1.06–1.08)

< 0.001

1.02 (1.01–1.04)

0.011

1.08 (1.04–1.13)

< 0.001

1.16 (1.11–1.20)

< 0.001

 BMI (×5 Kg/m2)

1.11 (1.09–1.12)

< 0.001

1.14 (1.12–1.17)

< 0.001

1.11 (1.09–1.14)

< 0.001

1.05 (1.02–1.08)

0.003

 eGFR< 60 mL/min/1.73 m2

2.19 (2.11–2.27)

< 0.001

2.99 (2.74–3.27)

< 0.001

2.27 (2.14–2.40)

< 0.001

1.82 (1.72–1.93)

< 0.001

 HbA1c (×1%)

1.22 (1.20–1.23)

< 0.001

1.21 (1.19–1.23)

< 0.001

1.24 (1.21–1.27)

< 0.001

1.19 (1.16–1.22)

< 0.001

 Triglycerides ≥150 mg/dl

1.26 (1.22–1.31)

< 0.001

1.40 (1.33–1.48)

< 0.001

1.19 (1.13–1.26)

< 0.001

1.19 (1.11–1.27)

< 0.001

 HDL < 40/< 50 mg/dL (Male/Female)

1.19 (1.15–1.23)

< 0.001

1.18 (1.11–1.24)

< 0.001

1.21 (1.14–1.28)

< 0.001

1.18 (1.11–1.26)

< 0.001

 LDL ≥100 mg/dL

0.92 (0.89–0.95)

< 0.001

0.89 (0.85–0.94)

< 0.001

0.94 (0.89–0.98)

0.010

0.92 (0.87–0.97)

0.002

 Blood Pressure ≥ 140/85 mmHg

1.47 (1.42–1.51)

< 0.001

1.49 (1.41–1.57)

< 0.001

1.45 (1.37–1.52)

< 0.001

1.47 (1.38–1.56)

< 0.001

 Smokinga

1.60 (1.52–1.68)

< 0.001

1.58 (1.47–1.70)

< 0.001

1.68 (1.54–1.84)

< 0.001

1.55 (1.35–1.79)

< 0.001

  1. The bold values refers to significant (p < 0.001) associations. Complete case analysis performed including patients for which all data were observed. Overall group included 115,493 patients: 23,973 (20.8%) with eGFR< 60 mL/min/1.73m2 and 33,598 (29.1% with albuminuria). Group with < 65 years included 43,945 patients: 2844 (6.5%) with eGFR< 60 mL/min/1.73m2 and 11,401 (25.9%) with albuminuria. Group with 65–75 years included 42,248 patients: 8746 (20.7%) with eGFR< 60 mL/min/1.73m2 and 12,170 (28.8%) with albuminuria. Group with > 75 years included 29,300 patients: 12,383 (42.26%) with eGFR< 60 mL/min/1.73m2 and 10,027 (34.2%) with albuminuria
  2. aModels including smoking status was analysed in 67,276 patients (27,431 with < 65 years, 24,249 with 65–75, and 15,596 with > 75 years)