From: Diabetic kidney disease in the elderly: prevalence and clinical correlates
Overall | p | < 65 years | p | 65–75 years | p | > 75 years | p | |
---|---|---|---|---|---|---|---|---|
Model for eGFR < 60 mL/min/1.73 m 2 | ||||||||
Male sex | 0.85 (0.82–0.88) | < 0.001 | 0.83 (0.76–0.90) | < 0.001 | 0.84 (0.80–0.88) | < 0.001 | 0.86 (0.82–0.91) | < 0.001 |
Age (×5 years) | 1.81 (1.79–1.83) | < 0.001 | 1.75 (1.67–1.82) | < 0.001 | 1.90 (1.82–1.99) | < 0.001 | 1.77 (1.72–1.83) | < 0.001 |
BMI (× 5 Kg/m2) | 1.19 (1.17–1.21) | < 0.001 | 1.13 (1.09–1.17) | < 0.001 | 1.18 (1.15–1.21) | < 0.001 | 1.23 (1.20–1.27) | < 0.001 |
Albuminuria | 2.14 (2.06–2.22) | < 0.001 | 2.90 (2.66–3.17) | < 0.001 | 2.22 (2.10–2.35) | < 0.001 | 1.78 (1.68–1.88) | < 0.001 |
HbA1c (×1%) | 1.00 (0.99–1.02) | 0.839 | 1.00 (0.97–1.03) | 0.979 | 1.01 (0.99–1.03) | 0.421 | 1.00 (0.98–1.02) | 0.976 |
Triglycerides ≥150 mg/dl | 1.69 (1.63–1.76) | < 0.001 | 1.85 (1.70–2.02) | < 0.001 | 1.73 (1.64–1.83) | < 0.001 | 1.58 (1.49–1.67) | < 0.001 |
HDL < 40/< 50 mg/dL (Male/Female) | 1.41 (1.36–1.46) | < 0.001 | 1.34 (1.23–1.46) | < 0.001 | 1.39 (1.32–1.47) | < 0.001 | 1.48 (1.40–1.56) | < 0.001 |
LDL ≥100 mg/dL | 0.88 (0.86–0.91) | < 0.001 | 0.80 (0.74–0.87) | < 0.001 | 0.90 (0.85–0.94) | < 0.001 | 0.91 (0.87–0.96) | < 0.001 |
Blood Pressure ≥ 140/85 mmHg | 0.87 (0.84–0.90) | < 0.001 | 1.00 (0.92–1.09) | 0.969 | 0.86 (0.82–0.91) | < 0.001 | 0.84 (0.79–0.88) | < 0.001 |
Smokinga | 0.79 (0.74–0.84) | < 0.001 | 0.73 (0.64–0.83) | < 0.001 | 0.81 (0.73–0.90) | < 0.001 | 0.82 (0.71–0.94) | 0.004 |
Model for Albuminuria | ||||||||
Male sex | 2.09 (2.02–2.15) | < 0.001 | 1.94 (1.83–2.05) | < 0.001 | 2.30 (2.18–2.42) | < 0.001 | 2.05 (1.93–2.17) | < 0.001 |
Age (×5 years) | 1.07 (1.06–1.08) | < 0.001 | 1.02 (1.01–1.04) | 0.011 | 1.08 (1.04–1.13) | < 0.001 | 1.16 (1.11–1.20) | < 0.001 |
BMI (×5 Kg/m2) | 1.11 (1.09–1.12) | < 0.001 | 1.14 (1.12–1.17) | < 0.001 | 1.11 (1.09–1.14) | < 0.001 | 1.05 (1.02–1.08) | 0.003 |
eGFR< 60 mL/min/1.73 m2 | 2.19 (2.11–2.27) | < 0.001 | 2.99 (2.74–3.27) | < 0.001 | 2.27 (2.14–2.40) | < 0.001 | 1.82 (1.72–1.93) | < 0.001 |
HbA1c (×1%) | 1.22 (1.20–1.23) | < 0.001 | 1.21 (1.19–1.23) | < 0.001 | 1.24 (1.21–1.27) | < 0.001 | 1.19 (1.16–1.22) | < 0.001 |
Triglycerides ≥150 mg/dl | 1.26 (1.22–1.31) | < 0.001 | 1.40 (1.33–1.48) | < 0.001 | 1.19 (1.13–1.26) | < 0.001 | 1.19 (1.11–1.27) | < 0.001 |
HDL < 40/< 50 mg/dL (Male/Female) | 1.19 (1.15–1.23) | < 0.001 | 1.18 (1.11–1.24) | < 0.001 | 1.21 (1.14–1.28) | < 0.001 | 1.18 (1.11–1.26) | < 0.001 |
LDL ≥100 mg/dL | 0.92 (0.89–0.95) | < 0.001 | 0.89 (0.85–0.94) | < 0.001 | 0.94 (0.89–0.98) | 0.010 | 0.92 (0.87–0.97) | 0.002 |
Blood Pressure ≥ 140/85 mmHg | 1.47 (1.42–1.51) | < 0.001 | 1.49 (1.41–1.57) | < 0.001 | 1.45 (1.37–1.52) | < 0.001 | 1.47 (1.38–1.56) | < 0.001 |
Smokinga | 1.60 (1.52–1.68) | < 0.001 | 1.58 (1.47–1.70) | < 0.001 | 1.68 (1.54–1.84) | < 0.001 | 1.55 (1.35–1.79) | < 0.001 |