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Table 2 Studies designed to investigate the effect of preoperative use of specific medicines on postoperative delirium

From: Preoperative medication use and postoperative delirium: a systematic review

Study (First author, publication year)

Preoperative medicines

Other covariates

OR or RR (95% CI)c

P-value

Katznelson, 2009b [34]

Beta-blockers

Age

History of cerebrovascular accident

Depression

OR 2.06 (1.18–3.60)

0.011

Statinsa

OR 0.56 (0.37–0.88)

0.011

Katznelson, 2009c [37]

Statinsa

Older age

Preoperative depression

Preoperative renal dysfunction

Complex cardiac surgery

Perioperative intraaortic balloon pump support

Massive blood transfusion

OR 0.54 (0.35–0.84)

0.010

Mariscalco, 2012 [36]

Statinsb

Age group

Cardiopulmonary bypass duration

OR 1.52 (0.97–2.37)

0.180

Kudoh, 2004 [30]

Benzodiazepines

Preoperative Mini-Mental State scores, anxiety

scores, depression scores

RR 2.10 (1.23–3.59)

0.007

  1. CI confidence interval, OR odds ratio, RR relative risk; a Protective effect; b Not associate; c only for preoperative medicines