Trajectories of physical function prior to death and brain neuropathology in a community-based cohort: the act study

Table 4 Relative risks^a for neuropathology outcomes for percentiles of estimated SPPB 5 years before death

	SPPB 5 years before death	Risk of neuropath outcomes
		RR^b	95%CI	P
CERAD (plaques) (intermediate/frequent)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	1.16	(0.94, 1.51)	0.24
40	7.86	1.35	(0.94, 2.17)	0.15
20^th percentile (lower SPPB)	6.46	1.55	(1.02, 2.73)	0.06
Braak (tangles) (V-VI)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	1.16	(0.87, 1.55)	0.31
40	7.86	1.33	(0.80, 2.24)	0.29
20^th percentile (lower SPPB)	6.46	1.47	(0.81, 2.80)	0.24
Amyloid angiopathy (mild, moderate, or severe)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	0.93	(0.70, 1.24)	0.63
40	7.86	0.89	(0.52, 1.48)	0.66
20th percentile (lower SPPB)	6.46	0.93	(0.51, 1.67)	0.78
Microinfarcts (>2 cerebral or deep)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	1.50	(0.88, 2.57)	0.13
40	7.86	2.24	(0.84, 6.01)	0.10
20^th percentile (lower SPPB)	6.46	3.08	(0.93, 10.07)	0.07
Cystic infarcts (1 or more)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	1.64	(1.17, 2.32)	0.002
40	7.86	2.42	(1.37, 4.51)	0.002
20^th percentile (lower SPPB)	6.46	2.72	(1.45, 5.57)	0.005
Atherosclerosis (2–3)
80^th percentile (higher SPPB)	9.98	Ref	–	–
60	9.02	1.17	(0.95, 1.39)	0.11
40	7.86	1.33	(0.93, 1.80)	0.10
20^th percentile (lower SPPB)	6.46	1.43	(0.96, 1.99)	0.08

^aEstimated via weighted GEE
^bRelative risks are computed for 20^th, 40^th, and 60^th percentiles relative to 80th percentiles from modified Poisson regression models adjusted for sex, age, BMI, and education

ISSN: 1471-2318