Trajectories of physical function prior to death and brain neuropathology in a community-based cohort: the act study

Table 3 Relative risks for neuropathology outcomes by rate of change in SPPB

	Rate of change of SPPB	Risk of neuropath outcomes
		RR	95%CI	P
CERAD (plaques) (intermediate/frequent)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	0.88	(0.74, 1.05)	0.14
40	−0.197	0.82	(0.62, 1.07)	0.158
20^th percentile (faster decline)	−0.251	0.80	(0.57, 1.14)	0.212
Braak (tangles) (V-VI)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	0.81	(0.65, 1.07)	0.12
40	−0.197	0.72	(0.51, 1.09)	0.11
20^th percentile (faster decline)	−0.251	0.66	(0.41, 1.02)	0.08
Amyloid angiopathy (mild, moderate, or severe)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	0.81	(0.63, 1.01)	0.09
40	−0.197	0.70	(0.47, 0.99)	0.07
20^th percentile (faster decline)	−0.251	0.58	(0.34, 0.92)	0.02
Microinfarcts (>2 cerebral or deep)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	1.06	(0.69, 1.61)	0.80
40	−0.197	1.15	(0.57, 2.22)	0.72
20^th percentile (faster decline)	−0.251	1.45	(0.55, 3.61)	0.41
Cystic infarcts (1 or more)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	1.35	(1.00, 1.82)	0.04
40	−0.197	1.58	(0.97, 2.50)	0.06
20^th percentile (faster decline)	−0.251	1.64	(0.84, 2.92)	0.11
Atherosclerosis (2–3)
80^th percentile (slower decline)	−0.124	Ref	–	–
60	−0.163	0.96	(0.85, 1.11)	0.51
40	−0.197	0.94	(0.79, 1.21)	0.59
20^th percentile (faster decline)	−0.251	0.98	(0.79, 1.35)	0.88

Relative risks are computed for 20th, 40th, and 60th percentiles of slope relative to 80th percentile of slope. Adjusted for sex, age, BMI, and education

ISSN: 1471-2318