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Table 2 Association of pre-operative medication use with post-operative delirium

From: Association of pre-operative medication use with post-operative delirium in surgical oncology patients receiving comprehensive geriatric assessment

Characteristics

No (%)

Delirium No (%)

P

  

Presence (n = 19)

Absence (n = 456)

 

Age (years)

   

0.018

Median (range)

76.0 (65.0–96.0)

79.0 (71.0–89.0)

76.0 (65.0–96.0)

 

Sex

   

0.157

Male

215 (45.3)

12 (63.2)

203 (44.5)

 

Female

260 (54.7)

7 (36.8)

253 (55.5)

 

BMI (kg/m2)a

   

0.054

Median (range)

23.6 (15.0–40.4)

21.9 (15.6–35.1)

23.7 (15.0–40.4)

 

CVD presenceb

   

0.609

Yes

343 (72.2)

15 (78.9)

328 (71.9)

 

No

132 (27.8)

4 (21.1)

128 (28.1)

 

Diabetes Presence

   

1.000

Yes

125 (26.3)

5 (26.3)

120 (26.3)

 

No

350 (73.7)

14 (73.7)

336 (73.7)

 

Dementia Presence

   

0.026

Yes

17 (3.6)

3 (15.8)

14 (3.1)

 

No

458 (96.4)

16 (84.2)

442 (96.9)

 

CrCla

   

0.776

≥50 mL/min

96 (21.1)

3 (15.8)

93 (21.3)

 

<50 mL/min

359 (78.9)

16 (84.2)

343 (78.7)

 

Cancer Type

   

0.179

Gastrointestinal

353 (74.3)

17 (89.5)

336 (73.7)

 

Othersc

122 (25.7)

2 (10.5)

120 (26.3)

 

Delirium Risk Scored

   

0.119

0–1

454 (96.8)

17 (89.5)

437 (97.1)

 

≥2

15 (3.2)

2 (10.5)

13 (2.9)

 

Polypharmacy

   

0.159

Yes

240 (50.5)

13 (68.4)

227 (49.8)

 

No

235 (49.5)

6 (31.6)

229 (50.2)

 

PDRM

   

1.000

Yes

272 (57.3)

11 (57.9)

261 (57.2)

 

No

203 (42.7)

8 (42.1)

195 (42.8)

 

DIM

   

<0.001

Yes

200 (42.1)

17 (89.5)

183 (40.1)

 

No

275 (57.9)

2 (10.5)

273 (59.9)

 

FIM

   

0.091

Yes

365 (76.8)

18 (94.7)

347 (76.1)

 

No

110 (23.2)

1 (5.3)

109 (23.9)

 

PIM

   

<0.001

Yes

127 (26.7)

12 (63.2)

115 (25.2)

 

No

348 (73.3)

7 (36.8)

341 (74.8)

 
  1. BMI body mass index, CVD cardiovascular disease, CrCl creatinine clearance, PDRM pre-operative discontinuation requiring medication, DIM delirium-inducing medication, FIM fall-inducing medication, PIM potentially inappropriate medication
  2. aThere were 20 missing data for BMI and CrCl
  3. bCVD included hypertension, ischemic heart disease (unstable angina, stable angina, myocardiac infarction), dyslipidemia, heart failure, atrial fibrillation, and cerebral infarction
  4. cOthers included 93 breast cancer, 15 gynecology cancer, 5 genitourinary cancer, and 9 other cancer patients
  5. dThere were 6 missing data for delirium risk score