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Feasibility and effects of applying stochastic resonance whole-body vibration on untrained elderly: a randomized crossover pilot study
BMC Geriatrics volume 15, Article number: 25 (2015)
Aging is associated with loss of balance and activity in daily life. It impacts postural control and increases the risk of falls. The current study was conducted to determine the feasibility and long-term impact of stochastic resonance whole-body vibration (SR-WBV) on static and dynamic balance and reaction time among elderly individuals.
A randomized crossover pilot study with blinding of the participants. Twenty elderly were divided into group A (SR-WBV 5 Hz, Noise 4/SR-WBV 1 Hz, Noise 1) or group B (SR-WBV 1 Hz, Noise 1/SR-WBV 5 Hz, Noise 1). Feasibility outcomes included recruitment, compliance and safety. Secondary outcomes were Semi-Tandem Stand (STS), Functional Reach Test (FRT), Expanded Timed Get Up-and-Go (ETGUG), walking under single (ST) & dual task (DT) conditions, hand and foot reaction time (RTH/RTF). Puri and Sen Rank-Order L Statistics were used to analyse carry-over effects. To analyse SR-WBV effects Wilcoxon signed-ranked tests were used.
With good recruitment rate (55%) and compliance (attrition 15%; adherence 85%) rates the intervention was deemed feasible. Three participants dropped out, two due to knee pain and one for personal reasons. ETGUG 0 to 2 m (p = 0.143; ES: 0.36) and ETGUG total time (p = 0.097; ES: 0.40) showed medium effect sizes.
Stochastic resonance training is feasible in untrained elderly resulting in good recruitment and compliance. Low volume SR-WBV exercises over 12 training sessions with 5 Hz, Noise 4 seems a sufficient stimulus to improve ETGUG total time. The stimulation did not elicit changes in other outcomes.
This trial has been registered at the U.S. National Institutes of Health under ClinicalTrials.gov: NCT01045746.
Postural balance skills of the elderly become increasingly limited due to normal or pathological ageing . These age related limitations in balance skills may be explained by changes in muscle mass, decreased reflex activity, mobility impairments, loss of somatosensory sensors as well as being due to an impairment of central processing, a deficit of motor response functions and a reduction in the functioning of the vestibular and visual systems [2,3]. These limitations are, furthermore, most likely associated with risk of injury or risk of falls [4-6]. A sedentary lifestyle in elderly individuals further increases the risk of falling whereas physically active elderly have a reduced risk, especially for falls resulting in injuries .
Despite the fact that physical activity (PA) for elderly is one of the major elements for general health prevention, too few elderly engage in PA . Inactive or sedentary elderly should, therefore, be motivated to increase their PA . It is important, however, to consider low baseline fitness and mobility levels in pre-frail or frail or rather untrained elderly when starting an exercise program. Elderly individuals with low baseline fitness and mobility levels who want to start a training program should start with an exercise program that meets their physical capabilities . These individuals are advised to first enter a “skilling up” phase before more traditional forms of training are implemented  in case their capabilities are low. The question of what kinds of exercises are appropriate for “skilling up”, however, remain to be explored . With this insight, trainers may prescribe balance exercises more effectively for untrained and frail elderly with different physical activity backgrounds who have impairments in static, dynamic or functional balance skills.
Systematic reviews concluded that, compared to more demanding interventions, whole body vibration (WBV) might be a more safe and less-fatiguing type of exercise  with beneficial effects on dynamic balance skills. Pilot studies showed that an intervention with stochastic resonance WBV (SR-WBV) in the elderly is both safe and feasible [13,14] and has positive effects on physical functioning . The use of SR-WBV might, therefore, be valuable for untrained or frail elderly where the neuromuscular systems might not be able withstanding higher loading and long training sessions .
There are two types of WBV devices on the market : sinusoidal (i.e. with a constant vibration frequency) and stochastic resonance vibration (i.e. with random vibration frequencies and harmonics) . During sinusoidal WBV participants stand on a single plate platform that vertically or side alternating vibrates with high frequency. Frequencies range between 20 to 50 Hz and amplitudes between 2 to 14 mm. Stochastic resonance whole-body vibration (SR-WBV) devices vibrate with frequencies between 1 and 12 Hz and amplitudes between 3 and 6 mm while the feet of the participants are placed on two independently powered stochastically resonating vibrating platforms .
However, there is a lack of evidence concerning the feasibility of implementing such exercise interventions in a primary training program aimed at “skilling up” of untrained elderly. New treatments usually have to go through a series of phases to test whether they are safe and effective  before larger scale studies and application in clinical practice are to be considered. The aim of this pilot study was to perform a phase II trial according the model for complex interventions advocated by the British Medical Research Council  to test the feasibility and effects of a SR-WBV program in a group of untrained elderly. The study aimed to (1) develop an exercise intervention based on principles of exercise theory and to deliver it to untrained elderly, (2) evaluate the feasibility of the intervention and the ability to recruit and retain elderly individuals, and (3) assess whether the treatment had some effect on physical performance.
The study used a crossover research design, involving 2 randomised groups (groups A and B) with blinding of the participants (Figure 1). The SR-WBV exercise was supervised and performed in a home-for-the-aged (Senevita Residenz Multengut, Muri, Switzerland), however, focused on individuals comparable with older community-dwellers independent in mobility functions and not on individuals comparable to nursing home residents. Group A started with the intervention while group B received a sham intervention. Treatments were reversed for the groups following a wash-out period. The assessor was not blinded to group allocation. The participants were familiarized with the treatment protocol one week prior to data collection.
Participants were included when fulfilling the following criteria: age over 65 years, able to stand with or without walking aids, classified as being only lightly dependent on nursing care according the BESA classification level 0, 1, 2a, living in the Canton of Berne and a having a score >22 in the Mini-Mental Status Examination (MMSE) Test. Exclusion criteria were: visual disturbancesb, lower or upper leg prosthesis, acute joint disease, acute thrombosis, acute fractures, acute infections, acute tissue damage, acute surgical scars or alcohol abuse.
Randomisation was performed by an independent research assistant. The participants were stratified by sex and were randomly assigned to either group A or group B. The blinded independent research assistant guaranteed concealed allocation sequence through the use of numbered sealed opaque envelopes distributed after the completion of all baseline assessments.
Written consent was obtained from all participants before enrolment in the study. The study protocol was approved by the Ethical Committee of Canton Berne (No.228/09) and was based on the declaration of Helsinki and registered under the U.S. National Institutes of Health (https://clinicaltrials.gov/) trial Number NCT01045746.
The participants were exposed to SR-WBV using a Zeptor med® device (Frei Swiss AG, Zurich, Switzerland) containing two three dimensionally vibrating plates (Figure 2). The participants were familiarized with the vibration treatment one week prior to the experiment. They stood freely on both legs wearing comfortable shoes. The participants were instructed to maintain a standing position with slight flexion of the hips, knees and ankle joints. In period 1, the participants in group A received 5 sets of 1 minute SR-WBV with 5 Hz, Noise 4 with 1 minute of rest between sets, three times a week, during four weeks. A minimum of one day rest in between training sessions was warranted. Participants in group B received a sham intervention of 5 sets of 1 minute SR-WBV with 1 Hz, Noise 1, where the 1 Hz frequency condition can be expected to have no training effect . After a wash-out period of 16 days, period 2 started. Group A received the sham intervention of 5 sets of 1 minute SR-WBV with 1 Hz, Noise 1 and group B received 5 sets of 1 minute SR-WBV with 5 Hz and Noise 4 during four weeks. The primary and secondary outcome variables were measured at baseline (T0) before training, after four weeks of training (T1) in period 1, and after the second four weeks intervention period (T3).
Recruitment rate, attrition, and program adherence
The criteria for success  of this pilot study were based on feasibility and focused on recruitment, attrition and adherence to the stochastic resonance WBV intervention. Recruitment of a third of the residents deemed eligible for the training, a 15% attrition rate, and 80% attendance rate  for the training were deemed acceptable.
For recruitment, data for the total sampling frame (both those approached and not approached) for inclusion in the trial were taken to assess generalizability to all elderly individuals within the facility. We measured the inclusion rate—i.e. the proportion of participants invited to participate who enrolled into the study—and distinguished between those who refused, did not respond or who were willing but excluded (volunteered but did not meet the study inclusion criteria). For attrition, we measured the number of participants lost at follow-up. For adherence to the intervention we recorded engagement with the intervention, e.g. compliance with all trainings. There were a total of 24 stochastic resonance WBV training sessions possible for each individual.
Semi-Tandem Stand (STS) was measured using a multi-component force platform (Kistler, Typ 9286BA, Winterthur, Switzerland). STS measurement with this approach has shown to be reliable . Each platform signal was transformed in an amplifier, digitally sampled with 1 kHz using a 12-bitA-/D-converter (Meilhaus, ME-2600i, SisNova, Engeneering, Zug, Switzerland) and analysed using ADS-Software-Program 1.12 (uk-labs, Kempen, Germany). The participants were instructed to perform STS for 20 seconds on the force platform. They were positioned by placing their right foot in the right upper quadrant and the left foot in the left lower quadrant of a custom built cadre that was removed after positioning. The arms were in a neutral position at the side of the body. The participants had to look straight ahead and fix their focal viewpoint on a green marker positioned at eye-level at a distance of 3 meters. Anterior-posterior (AP) and medial-lateral (ML) sway during the STS was calculated from force-time curves. The test was repeated twice with a rest of 1 minute in between.
Functional Reach Test (FRT) was used to quantify dynamic balance . This test is both valid and reliable  for the target population. A yardstick is attached to a wall at about shoulder-height. The participant stands facing the wall, with the arm in 90° anteflexion, and reaches maximally forward without moving the feet. The FRT has been associated with an increased risk of falls and frailty in elderly unable to reach more than 15 cm forward . The measurement data were obtained from the best three attempts out of five and averaged.
The Expanded Timed Get Up-and-Go (ETGUG), a reliable clinical assessment, measured time series of functionally important tasks using a multimemory stopwatch [25,26]. The participants were asked to rise from a chair, to walk at their normal speed to the end of the walkway, to turn around and to walk and sit back on the chair. At 2, 8 and 10 meters along the walkway, markers were set (using coloured tape on the floor), allowing measurement of the mean times. Measurements were conducted using a digital hand stopwatch (Timex: Ironmen Triathlon, Middlebury, CL, USA). The test was repeated twice with minimum of one minute rest in between.
Gait of each participant was assessed during usual walking at preferred velocity under single and dual task conditions over a distance of 20 m in a corridor of the Senevita Residenz Multengut Muri (Switzerland) with a digital hand stopwatch (Timex: Ironmen Triathlon, Middlebury, CL, USA). The test was repeated twice with a minimum of one minute rest in between. Gait assessment at preferred velocity informs about actual, subject-specific behaviour  which is indicative of a decrease in the performance of gait in senior adults who have fallen and may be related to diminished strength, balance, and tactile sensation . The measurement device and testing protocol have previously been described and identified as being reliable in older adults .
Simple reaction time was measured from both hand (RTH) and foot (RTF) to measure psychomotor speed in milliseconds using a hand-held electronic timer and a light as the stimulus and depression of a switch by the finger and the foot as the responses [30,31]. Participants performed 5 practice and 10 experimental trials.
For safety reasons, the participants were interviewed before and immediately after vibration training on their well-being, feelings of (in)stability and for adverse effects such as dizziness and pain during vibration. Discontinuations of participation in the study were noted.
This pilot study used nonparametric statistical analyses. Mann–Whitney U test assess baseline characteristics (T0) and treatment effects between group A and group B. Puri and Sen L Statistics for Ranked Data  analysed carry-over effects. Carry-over effects were compared with a two-factorial analysis of variance with repeated measures . Pillai’s Trace was used to calculate L. In case a carry-over effect was present, the data were analysed with the first period data only: e.g., similar to a parallel design . In case no carry-over effect was present, treatment effects were calculated with Mann–Whitney U test from both periods. The difference in mean from period 1 minus period 2 was compared between the groups .
The results are reported as an estimate of the intervention effect as mean ± SDs. P-values < 0.05 were considered significant. All analyses were conducted using SPSS Version 19.0 for Windows (SPSS Inc., Chicago, IL, USA) and the statistical function of the Microsoft® Excel® 2008 for Mac Version12.2.7 software. The magnitude of effects were calculated and expressed as r = Z/√N. For r an effect size of 0.1 is considered a “small” effect, around 0.3 a “medium” effect and 0.5 and above, a ‘large’ effect . In addition, participants’ compliance to the treatment protocol was calculated using the following formula: Number of vibration sessions ÷ the total number of possible vibration sessions x 100.
The program G*Power 3 was used for the post hoc calculation of power (www.psycho.uni-duesseldorf.de/abteilungen/aap/gpower3/). The CONSORT 2010 guidelines regarding randomised trials (www.consort-statement.org) and recommendations of items to include when reporting a pilot study  were followed for describing the results of this pilot.
Figure 1 describes the flow of the participants through the study. Socio-demographic and anthropometric characteristics are summarized in Table 1. None of the participants reported any injuries or medical conditions that could affect their balance. Participants reported to being generally healthy.
Recruitment, attrition, and adherence
The facility had a total of 100 residents from which staff representatives estimated 65 fulfilled eligibility criteria and, therefore, represented the potential sampling frame. Two information sessions were held and attended by 45 residents. From these 45 persons, 25 persons were deemed eligible and were invited to participate. 20 eligible persons (10 women, 79.85 ± 6.6 years and 10 men, 78 ± 7.3 years) were recruited and enrolled in the study resulting in a recruitment rate of approximately 55%. Inclusion rate—i.e. the proportion of participants invited to participate who enrolled—was 80%. The participants were willing to be randomized. Seventeen elderly individuals participated at follow-up measurements that resulted in a 15% attrition rate. Three participants dropped out during the training sessions. Two participants discontinued training due to knee pain unrelated to the training and one for personal reasons (Table 2). The number of SR-WBV sessions completed divided by the possible training sessions was 95%, leading to excellent adherence to the study protocol over the four weeks training periods. Neither subjective nor objective side-effects related to the used intervention were reported.
No carry-over effect was found for any of the outcomes measures (Table 2). Table 3 summarizes the main outcome results for all outcome measures. ETGUG 0 to 2 m (p = 0.143; ES: 0.36) and ETGUG total time (p = 0.097; ES: 0.40) showed no significant changes albeit medium effect sizes. The other values presented no significant changes combined with small effect sizes.
This randomized cross-over pilot study tested the feasibility of SR-WBV training applied to untrained elderly living in a home-for-the-aged. Furthermore, this study investigated the effects of a four-week SR-WBV training on static and dynamic balance and reaction time. The main findings showed that a randomised controlled cross-over trial with SR-WBV is both feasible and safe for untrained elderly. Those individuals that responded and visited an information session showed a large inclusion rate and in majority remained in the intervention until completion. These findings indicate the importance of information sessions for elderly individuals where questions and concerns about new interventions can be met.
This pilot study provided useful information about the feasibility of the experimental intervention that used SR-WBV for “skilling-up” training. Our participants tolerated the SR-WBV intervention. They were also able to progress in intensity and duration of the exercises. However, our experience suggests that our SR-WBV component was not of sufficient duration and/or intensity to ameliorate physical functioning capacity as indicated by no improvements in the secondary outcomes. Neither group showed improvements or tendencies towards improvement in any of the outcome parameters within the program duration of four weeks. This finding might be attributed to a lack of power due to the sample size used or is due to the time frame of the intervention. Kawanabe and colleagues  indicated that effects of WBV training in the elderly may be expected after a two months study period. We believe, therefore, that it is feasible to proceed to a sufficiently powered main study only with major modifications to the protocol; e.g. adapt the intensities and/or length of training. It might well be, for example, that we should increase the frequency of the SR-WBV vibration. The current pilot study used a frequency with 5 Hz, Noise 4. Haas  and Turbanski  used in their studies effective frequencies of 6 Hz. In a future study, the amplitude of vibration should possibly be 6 Hz.
Summarising the findings and limitations of this study it becomes clear that this study only reveals first estimates for the chosen outcome measures. We implemented a strict study design to control threats to validity. A next step would be to replicate the findings in a new exercise group of institutionalised elderly individuals as an additional control procedure. Although we are aware of the fact that the emphasis of a pilot study should be placed on feasibility and not on statistical significance  our data allow for a sample size calculation for a future trial. To avoid a type I or II error in this future trial we need, based on our observed value for the ETGUG total time (with values of the last training of EXPERIMENTAL = 13.5 ± 3.1 s; CONTROL = 19.3 ± 7.9 s), an estimated sample size of 50 participants per group for a two group pretest-posttest design. This would result in 80% power at an α-level of 0.05 and is based on the assumption that the standard deviation of the response variable is 5.5. To account for attrition over time, the required sample size should increase by 15%. It should be stressed, however, that this sample size calculation should be interpreted with caution because our estimates may be unrealistic or biased because of the limited sample size .
We conclude that pilot studies with explicit feasibility objectives and success criteria are important foundation steps in preparing for large trials  and for development of Rehabilitation research programs . Ongoing formal review of the multifaceted issues inherent in the design and conduct of pilot studies can provide invaluable feasibility and scientific data for rehabilitation specialists, e.g. physiotherapists, willing to perform clinical trials  and may also be highly relevant for furthering the development of theory based rehabilitation . SR-WBV training is feasible and, although not showing significant effects, shows trends to stronger improvement in the overall time to complete a series of functionally important tasks as assessed with the ETGUG with a medium to large effect size of 0.4. The application in a main study is deemed feasible, however, with a need for protocol modifications. A minimum of ± 55 participants per group are required to achieve a power of 80% at the 5% level of significance based on ETGUG total time and considering the expectable attrition rate in a required larger scale study. This study encourages the further development of this intervention, preferably with a randomized control design.
aBESA and its assessment instruments are based on the results of scientific research. Thanks to the four steps of BESA – clarification of the available resources, agreements concerning the aims of health care, taxation of the costs and improvement of the quality level of health care – the main elements of the process of health are systematically sustained. BESA is actually used in more than 400 homes or residences for elderly people in Switzerland.
bVisual disturbances are abnormalities of sight and associated with neurological disorders (diabetes), often include double vision, moving vision like nystagmus, blindness or reduced view field.
Expanded timed get up-and-go
Functional reach test
Mini-mental status examination
Foot reaction time
Hand reaction time
Stochastic resonance whole-body vibration
Lacour M, Bernard-Demanze L, Dumitrescu M. Posture control, aging, and attention resources: models and posture-analysis methods. Neurophysiol Clin. 2008;38(6):411–21.
Goble DJ, Coxon JP, Wenderoth N, Van Impe A, Swinnen SP. Proprioceptive sensibility in the elderly: degeneration, functional consequences and plastic-adaptive processes. Neurosci Biobehav Rev. 2009;33(3):271–8.
Rosso AL, Studenski SA, Chen WG, Aizenstein HJ, Alexander NB, Bennett DA, et al. Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci. 2013;68(11):1379–86.
Pizzigalli L, Filippini A, Ahmaidi S, Jullien H, Rainoldi A. Prevention of falling risk in elderly people: the relevance of muscular strength and symmetry of lower limbs in postural stability. J Strength Cond Res. 2011;25(2):567–74.
Skelton DA, Dinan SM. Exercise for falls management: Rationale for an exercise programme aimed at reducing postural instability. Physiother Theory Pract. 1999;15(2):105–20.
Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319(26):1701–7.
Thibaud M, Bloch F, Tournoux-Facon C, Brèque C, Rigaud A, Dugué B, et al. Impact of physical activity and sedentary behaviour on fall risks in older people: a systematic review and meta-analysis of observational studies. Eur Rev Aging Phys Act. 2011;8(1):5–15.
Baert V, Gorus E, Mets T, Geerts C, Bautmans I. Motivators and barriers for physical activity in the oldest old: a systematic review. Ageing Res Rev. 2011;10(4):464–74.
Freiberger E, Sieber C, Pfeifer K. Physical activity, exercise, and sarcopenia - future challenges. Wien Med Wochenschr. 2011;161(17–18):416–25.
Gardner MM, Buchner DM, Robertson MC, Campbell AJ. Practical implementation of an exercise-based falls prevention programme. Age Ageing. 2001;30(1):77–83.
Landi F, Abbatecola AM, Provinciali M, Corsonello A, Bustacchini S, Manigrasso L, et al. Moving against frailty: does physical activity matter? Biogerontol. 2010;11(5):537–45.
Chanou K, Gerodimos V, Karatrantou K, Jamurtas A. Whole-body vibration and rehabilitation of chronic diseases: a review of the literature. J Sports Sci Med. 2012;11(2):187–200.
Rogan S, Schmidtbleicher D, Radlinger L. Immediate effects after stochastic resonance whole-body vibration on physical performance on frail elderly for skilling-up training: a blind cross-over randomised pilot study. Aging Clin Exp Res. 2014;26(5):519–27.
Rogan S, Radlinger L, Schmid S, Herren K, Hilfiker R, de Bruin E. Skilling up for training: a feasibility study investigating acute effects of stochastic resonance whole-body vibration on postural control of older adults. Ageing Res. 2012;4:e5.
Rogan S, Hilfiker R, Schmid S, Radlinger L. Stochastic resonance whole-body vibration training for chair rising performance on untrained elderly: a pilot study. Arch Gerontol Geriatr. 2012;55(2):468–73.
Herren K, Holz Hängärtner C, Oberli A, Radlinger L. [Cardiovascular and metabolic strain during stochastic resonance therapy in stroke patients]. Physioscience. 2009;5(1):13.
Rogan S, Hilfiker R, Herren K, Radlinger L, de Bruin ED. Effects of whole-body vibration on postural control in elderly: a systematic review and meta-analysis. BMC Geriatr. 2011;11:72.
Rogan S, Hilfiker R. [Training methods - increase muscle strength due to whole-body vibration - force with Hz]. Sportverletz Sportschaden. 2012;26(4):185–7.
Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol. 2010;10:1.
Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ. 2008;337:a1655.
van Tulder M, Furlan A, Bombardier C, Bouter L, Editorial Board of the Cochrane Collaboration Back Review G. Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine. 2003;28(12):1290–9.
Ritchie C, Trost SG, Brown W, Armit C. Reliability and validity of physical fitness field tests for adults aged 55 to 70 years. J Sci Med Sport. 2005;8(1):61–70.
Duncan PW, Weiner DK, Chandler J, Studenski S. Functional reach: a new clinical measure of balance. J Gerontol. 1990;45(6):M192–7.
Weiner DK, Duncan PW, Chandler J, Studenski SA. Functional reach: a marker of physical frailty. J Am Geriatr Soc. 1992;40(3):203–7.
Botolfsen P, Helbostad JL, Moe-Nilssen R, Wall JC. Reliability and concurrent validity of the Expanded Timed Up-and-Go test in older people with impaired mobility. Physiother Res Int. 2008;13(2):94–106.
Wall JC, Bell C, Campbell S, Davis J. The Timed Get-up-and-Go test revisited: measurement of the component tasks. J Rehabil Res Dev. 2000;37(1):109–13.
Hamacher D, Singh NB, Van Dieen JH, Heller MO, Taylor WR. Kinematic measures for assessing gait stability in elderly individuals: a systematic review. J R Soc Interface. 2011;8(65):1682–98.
Nelson AJ, Certo LJ, Lembo LS, Lopez DA, Manfredonia EF, Vanichpong SK, et al. The functional ambulation performance of elderly fallers and non-fallers walking at their preferred velocity. NeuroRehabilitation. 1999;13(3):141–46.
Bohannon RW. Comfortable and maximum walking speed of adults aged 20–79 years: reference values and determinants. Age Ageing. 1997;26(1):15–9.
Lord SR, Castell S. Physical activity program for older persons: effect on balance, strength, neuromuscular control, and reaction time. Arch Phys Med Rehabil. 1994;75(6):648–52.
Lord SR, Clark RD, Webster IW. Postural stability and associated physiological factors in a population of aged persons. J Gerontol. 1991;46(3):M69–76.
Thomas JR, Nelson JK, Thomas KT. A generalized rank-order method for nonparametric analysis of data from exercise science: a tutorial. Res Q Exerc Sport. 1999;70(1):11–23.
Cleophas TJ, Zwinder AH, Cleophas TF, Cleophas EP. Statistics applied to clinical trials, 5th edn: Springer; 2012.
Hills M, Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol. 1979;8(1):7–20.
Corder GW, Foreman DI. Nonparameztric statistics for non-statisticans . a step-by-step approach. Hoboken, New Jersey: John Wiley & Sons. Inc; 2009.
Kawanabe K, Kawashima A, Sashimoto I, Takeda T, Sato Y, Iwamoto J. Effect of whole-body vibration exercise and muscle strengthening, balance, and walking exercises on walking ability in the elderly. Keio J Med. 2007;56(1):28–33.
Haas CT, Schmidtbleicher D. Potential of Stochastic Resonance in Neurorehabilitation. Isokinetic Exerc Sci. 2006;14(2):144–6.
Turbanski S, Haas CT, Schmidtbleicher D, Friedrich A, Duisberg P. Effects of random whole-body vibration on postural control in Parkinson’s disease. Res Sports Med. 2005;13(3):243–56.
de Bruin ED, van Het Reve E, Murer K. A randomized controlled pilot study assessing the feasibility of combined motor-cognitive training and its effect on gait characteristics in the elderly. Clin Rehabil. 2012;27(3):215–25.
Cook DJ, Rocker G, Meade M, Guyatt G, Geerts W, Anderson D, et al. Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study. J Crit Care. 2005;20(4):364–72.
This study project was funded by the Bern University of Applied Sciences, Department Health (aR&D Physiotherapy) and Senevita Residenz Multengut, Muri. Both institutions covered costs for insurance fees, ethical committee assessment and advertisement in the newspaper. The funding agency played no role in the design, conduct, or reporting of the study or in the decision to submit the article for publication. We would like to thank Ross Bennie for proof reading.
The authors declare that they have no competing interests.
SR, LR and DS conceived the idea of this study. SR, LR, RH, DS and EdB participated in the conception and design of the study; RH managed the randomising. SR and RH supervised the WBV trainings session and Data collection. SR conducted the statistical analyses. SR, LR, RH and EdB wrote the manuscript. SR, LR, RH, DS, RdB, and EdB were involved in drafting or revising the manuscript. All authors read and approved the final manuscript.
Slavko Rogan, Lorenz Radlinger, Roger Hilfiker and Eling D de Bruin contributed equally to this work.
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Rogan, S., Radlinger, L., Hilfiker, R. et al. Feasibility and effects of applying stochastic resonance whole-body vibration on untrained elderly: a randomized crossover pilot study. BMC Geriatr 15, 25 (2015) doi:10.1186/s12877-015-0021-4
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