Skip to main content

Table 4 Risk of Fall in Occasional and Regular Users of Inappropriate Medication compared to Never Users

From: Inappropriate medication use and risk of falls – A prospective study in a large community-dwelling elderly cohort

 

≤ 1 fall

≥ 2 falls

    

Medication n (%)

(N = 4961)

(N = 1382)

OR (95% CI)

crude P-Value

OR (95% CI)*†

P-Value†

Inappropriate medication full list

      

   Occasional user‡

809 (16)

277 (20)

1.48 (1.26–1.74)

<.001

1.23 (1.04–1.45)

.016

   Regular user §

1389 (28)

465 (34)

1.45 (1.26–1.66)

<.001

1.08 (0.94–1.25)

.29

Inappropriate medication without cerebral vasodilators

      

   Occasional user

704 (14)

239 (17)

1.38 (1.17–1.63)

<.001

1.22 (1.02–1.45)

.030

   Regular user

826 (17)

300 (22)

1.48 (1.27–1.72)

<.001

1.19 (1.00–1.41)

.049

Long-acting benzodiazepines

      

   Occasional user

286 (9)

117 (13)

1.58 (1.26–1.98)

<.001

1.40 (1.10–1.79)

.006

   Regular user

316 (9)

135 (15)

1.65 (1.33–2.04)

<.001

1.41 (1.12–1.79)

.004

Inappropriate psychotropic drugs

      

   Occasional user

102 (2)

37 (3)

1.33 (0.91–1.95)

.14

1.17 (0.74–1.83)

.50

   Regular user

74 (1)

39 (3)

1.93 (1.30–2.86)

.001

1.74 (1.14–2.66)

.010

Inappropriate medication with anticholinergic properties

      

   Occasional user

264 (5)

91 (7)

1.29 (1.01–1.65)

.042

1.21 (0.93–1.58)

.15

   Regular user

172 (3)

84 (6)

1.83 (1.40–2.40)

<.001

1.57 (1.18–2.10)

.002

Short- or intermediate-half-life benzodiazepines

      

   Occasional user

429 (9)

151 (11)

1.34 (1.10–1.63)

.004

1.20 (0.96–1.49)

.11

   Regular user

441 (9)

153 (11)

1.32 (1.08–1.60)

.006

1.05 (0.83–1.32)

.69

  1. * Reference group: Never user of inappropriate medication
  2. ‡ Occasional user: exposure at only one of the 3 examinations (baseline and 2 follow-up)
  3. §Regular user: exposure at two or three examinations
  4. † Adjusted for age, sex, study centre, Body Mass Index, diurnal drowsiness, number of drugs (excluding IM), cognitive functioning, depressive symptoms and impaired mobility.