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Table 3 Immune phenotypes as a function of age, sex, frailty and nutritional status

From: Immunosenescence in the nursing home elderly

Immune phenotype

Age Correlation+(r) n = 262

Sex Median (IQR) n = 262++

Clinical Frailty Scale Median (IQR) n = 262+++

Nutritional Status Median (IQR) n = 261a+++

  

Female n = 213

Male n = 49

4 n = 64

5 n = 62

6 n = 94

7 or 8 n = 42

Normal n = 127

At risk n = 121

Mal-nourished n = 13

CD8+

CD8 + %

0.05

17.1

17.4

18.6

17.6

16.3

16.3

17.4

17.1

17.1

(11.8-24.2)

(12.8-22.2)

(13.7-23.8)

(12.3-21.9)

(11.7-24.1)

(9.7-26.8)

(12.2-23.8)

(11.7-24.2)

(11.2-20.9)

Naïve CD8 + %

−0.13*

0.9

0.8

0.9

0.8

1.0

1.2

0.9

1.0

0.7

(0.5-1.5)

(0.4-1.2)

(0.5-1.4)

(0.5-1.4)

(0.5-1.4)

(0.5-2.1)

(0.5-1.4)

(0.58-1.6)

(0.3-1.2)

Central memory CD8 + %

−0.03

0.6

0.5

0.5

0.5

0.6

0.7

0.5

0.7

0.5

(0.3-1.0)

(0.3-0.8)

(0.3-0.9)

(0.3-0.9)

(0.3-1.0)

(0.3-1.5)

(0.3-0.9)

(0.3-1.1)

(0.4-0.9)

Effector memory CD8 + %

−0.04

6.1

7.1

6.7

6.3

6.3

5.7

6.5

6.0

6.0

(3.8-9.5)

(4.5-9.7)

(4.1-9.9)

(4.1-8.7)

(3.7-10.0)

(4.0-8.6)

(3.8-9.9)

(3.9-8.8)

(4.0-10.9)

Terminally differentiated CD8 + %

0.08

7.8

5.9

8.9

7.6

6.9

6.1

8.1

7.2

5.8

(3.6-12.6)

(3.3-12.5)

(4.2-13.3)

(3.7-12.8)

(3.4-11.0)

(2.4-12.9)

(3.5-12.7)

(3.6-12.5)

(3.1-10.9)

Senescent CD8 + %

0.04

5.1

5.7

6.2

5.0

5.1

4.9

5.1

5.2

5.6

(2.3-8.9)

(2.0-11.3)

(2.8-11.4)

(2.3-9.3)

(2.2-7.9)

(0.8-10.0)

(2.2-10.0)

(2.3-8.6)

(1.2-9.5)

CD4+

CD4 + %

−0.06

46.1*

42.1*

44.9

45.8

46.4

43.1

46.1

45.8

42.0

(39.1-53.8)

(34.7-49.1)

(38.6-53.6)

(37.1-52.6)

(40.4-53.1)

(32.4-52.7)

(38.7-52.6)

(36.1-53.5)

(35.9-44.9)

Naïve CD4 + %

0.05

10.1*

7.1*

10.5

9.2

9.3

7.2

10.4*

8.7*

5.9*

(5.4-14.6)

(4.6-11.5)

(5.4-18.0)

(5.3-14.7)

(5.4-13.1)

(4.0-12.2)

(5.4-16.1)

(4.8-12.5)

(3.4-9.9)

Central memory CD4 + %

−0.08

12.8

11.7

12.5

12.0

13.3

12.8

12.5

13.1

10.7

(9.6-16.4)

(8.7-14.6)

(9.0-15.4)

(8.4-16.2)

(10.7-18.2)

(8.7-15.8)

(9.2-16.2)

(9.0-17.2)

(9.3-13.3)

Effector memory CD4 + %

0.13*

18.9

18.2

19.3

18.1

19.2

17.0

18.6

19.0

18.5

(14.6-23.0)

(12.9-21.4)

(13.6-21.8)

(12.7-21.9)

(15.2-24.2)

(13.5-22.4)

(13.5-21.8)

(14.6-22.8)

(12.8-26.6)

Terminally differentiated CD4 + %

0.05

1.9*

1.4*

1.9

1.8

1.6

1.8

1.9

1.6

1.4

(1.1-2.9)

(0.6-2.5)

(1.1-3.3)

(1.1-2.6)

(1.1-2.7)

(0.8-2.7)

(1.1-2.9)

(1.0-2.8)

(0.9-2.0)

Senescent CD4 + %

0.11

1.4

1.3

1.5

1.4

1.4

1.2

1.4

1.3

2.0

(0.3-3.5)

(0.2-2.9)

(0.3-4.2)

(0.1-3.1)

(0.3-3.6)

(0.2-2.9)

(0.16-3.4)

(0.27-3.2)

(0.34-4.4)

T-reg

T-reg%

0.08

1.8

1.6

2.5 **

2.0**

1.6**

1.0**

2.2**

1.6**

1.0**

(1.2-2.6)

(0.9-2.6)

(1.8-2.9)

(1.3-2.6)

(1.1-2.3)

(0.8-1.5)

(1.5-2.9)

(1.1-2.3)

(0.8-1.2)

Ratio

 

CD4 + : CD 8 + ratio

−0.06

2.6

2.5

2.5

2.4

2.7

2.6

2.6

2.6

2.3

(1.7-4.5)

(1.6-3.5)

(1.6-3.8)

(1.8-4.1)

(1.9-4.5)

(1.4-5.0)

(1.7-4.1)

(1.6-4.5)

(1.8-3.3)

NK

Mature NK cell%

−0.05

12

12.6

12.0

11.3

12.3

12.7

12.3

11.6

14.7

(8.0-16.6)

(7.1-17)

(8.3-6.3)

(7.1-15.2)

(7.3-16.7)

(8.5-17.2)

(8.7-16.0)

(6.8-16.5)

(7.9-18.4)

Senescent NK cell%

−0.10

1.4

1.5

1.0**

1.1**

1.7**

2.0**

1.3*

1.6*

1.4*

(0.9-2.2)

(1.0-2.4)

(0.7-1.9)

(0.7-1.9)

(1.0-2.7)

(1.3-2.7)

(0.74-2.1)

(1.0-2.7)

(1.1-2.3)

Immature NK cell%

0.03

0.2

0.3

0.2

0.21

0.3

0.3

0.2

0.2

0.2

(0.1-0.4)

(0.1-0.5)

(0.1-0.4)

(0.1-0.3)

(0.2-0.4)

(0.2-0.4)

(0.2-0.4)

(0.1-0.4)

(0.13-0.45)

  1. *p ≤ 0.05.
  2. **p ≤ 0.001.
  3. aOne patient excluded as nutritional status unknown.
  4. +Spearman’s rank test of significance used.
  5. ++Mann–Whitney U test of significance used.
  6. +++Kruskal-Wallis test of significance used.
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BMC Geriatrics

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