Table 2 Immune phenotypes in the nursing home elderly compared to healthy adults
Immune phenotype | Nursing home elderly | Healthy adults | p-value* |
|---|---|---|---|
Median (IQR) | Median (IQR) | ||
n = 262 | n = 16 | ||
CD8+ | |||
CD8 + % | 17.1 (11.9 – 23.9) | 18.0 (15.1 – 21.0) | 0.56 |
Naïve CD8 + % | 0.90 (0.5 – 1.4) | 5.2 (3.8 – 7.9) | <0.001 |
Central memory CD8 + % | 0.6 (0.3 – 1.0) | 0.5 (0.4 – 0.8) | 0.86 |
Effector memory CD8 + % | 6.3 (3.9 – 9.4) | 8.1 (6.6 – 10.1) | 0.14 |
Terminally differentiated CD8 + % | 7.3 (3.5 – 12.5) | 4.1 (2.0 – 6.0) | 0.004 |
Senescent CD8 + % | 5.3 (2.2 – 9.4) | 3.1 (0.7 – 6.2) | 0.04 |
CD4+ | |||
CD4 + % | 45.5 (38.0 - 52.7) | 37.1 (29.7 - 43.1) | 0.001 |
Naïve CD4 + % | 9.2 (5.1 – 13.7) | 11.6 (7.1 - 15.4) | 0.19 |
Central memory CD4 + % | 12.6 (9.1 - 16.2) | 8.4 (6.5 - 13.2) | 0.003 |
Effector memory CD4 + % | 18.6 (14.1 - 22.6) | 12.3 (11.8 - 15.8) | <0.001 |
Terminally differentiated CD4 + % | 1.8 (1.1 – 2.8) | 1.2 (0.6 - 2.1) | 0.09 |
Senescent CD4 + % | 1.4 (0.2 - 3.4) | 0.8 (0.1-2.0) | 0.21 |
T-reg | |||
T-reg% | 1.8 (1.1 – 2.6) | 0.8 (0.6 – 0.9) | <0.001 |
Ratio | |||
CD4 + : CD 8 + ratio | 2.6 (1.7 – 4.1) | 1.9 (1.6 – 2.6) | 0.048 |
NK | |||
Mature NK cell% | 12.1 (7.9 – 16.6) | 5.4 (2.7 – 10.0) | 0.001 |
Senescent NK cell% | 1.4 (0.89 – 2.2) | 1.7 (1.5 – 2.6) | 0.27 |
Immature NK cell% | 0.2 (0.1 – 0.4) | 0.3 (0.04 – 0.7) | 0.57 |