Table 3 Model 1: Effects of cognitive impairment (CDR sum of boxes) measured at baseline on P-ADL level over time estimated by linear mixed model with random effects for intercepts and time

Effect of main variables ¹

Time

0.19 (0.15; 0.24)

<0.001

0.20 (0.16; 0.25)

<0.001

Time* time

-0.001 (-0.001; -0.0005)

<0.001

-0.001 (-0.002; -0.001)

<0.001

CDR sum of boxes

0.72 (0.65; 0.79)

<0.001

0.61 (0.53; 0.69)

<0.001

Time* CDR sum of boxes

-0.004 (-0.007; -0.001)

0.007

-0.004 (-0.007; -0.001)

0.013

Effect of additional variables at baseline ²

Length of stay

0.002 (0.001; 0.002)

<0.001

0.001 (0.001; 0.001)

<0.001

Socio –demographic information

Age (years)

-0.02 (-0.06; 0.02)

0.312

-0.05 (-0.09; -0.01)

0.007

Women

-0.33 (-1.03; 0.38)

0.362

-0.62 (-1.25; 0.01)

0.054

Single

-0.80 (-1.58; -0.03)

0.042

-0.72 (-1.41; -0.03)

0.041

Ten years of education or less

0.46 (-0.25; 1.17)

0.206

0.48 (-0.12; 1.07)

0.117

Somatic health difficulties

Co-morbidity index

0.21 (-0.04; 0.46)

0.100

0.32 (0.11; 0.53)

0.003

No severe vision impairment

1.65 (0.77; 2.53)

<0.001

0.93 (0.19; 1.67)

0.014

No severe hearing impairment

-0.79 (-1.70; 0.13)

0.091

-0.12 (-0.90; 0.66)

0.765

Degree of neuropsychiatric problems

Agitation sub-syndrome

0.08 (0.04; 0.12)

<0.001

0.01 (-0.0; 0.04)

0.546

Psychosis sub- syndrome

0.04 (-0.02; 0.10)

0.150

Affective sub-syndrome

0.02 (-0.04; 0.07)

0.602

Apathy

0.35 (0.27; 0.43)

<0.001

0.10 (0.03; 0.18)

0.007

Use of psychotropic medication

Antipsychotics

0.72 (0.01; 1.42)

0.046

-0.08 (-0.69; 0.53)

0.802

Antidepressants

-0.56 (-1.19; 0.07)

0.081

-0.33 (-0.86; 0.20)

0.225

Anxiolytics

-0.28 (-1.01; 0.44)

0.443

-0.70 (-1.31; -0.10)

0.024

Sedatives

-0.65 (-1.36; 0.05)

0.070

-0.12 (-0.70; 0.47)

0.701

Cognitive enhancers

-3.23 (-4.09; -2.36)

<0.001

-1.81 (-2.58; -1.05)

<0.001