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Table 2 Odds ratios for associations with MMSE score and Self-reported health based on logistic regression analyses

From: Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China

Dependent variable

MMSE score (Good/moderate/Poor)

Self-reported good health

(Model I, based on ordered logistic regression)

(Model II based on binary logistic regression)

Genotype included in model

rs1042718

rs1042719

rs1042718

rs1042719

Model code

I-A1

I-A2

I-A3

I-A4

I-B1

I-B2

I-B3

I-B4

II-A1

II-A2

II-A3

II-A4

II-B1

II-B2

II-B3

II-B4

rs1042718 carrier (non-carrier)

1.00

0.83

0.99

1.54*

    

1.12

0.91

1.03

1.57*

    

rs1042719 carrier (non-carrier)

    

1.04

0.96

1.04

1.65*

    

0.97

0.73

0.77

1.14

Male (female)

1.60**

1.61**

1.59**

1.56**

1.68***

1.68***

1.68***

1.65**

1.42*

1.42

1.41

1.40

1.39

1.39

1.36

1.37

Urban (rural)

1.03

1.04

1.03

1.04

1.06

1.06

1.06

1.05

1.24

1.26

1.25

1.26

1.27

1.28

1.27

1.27

Age

0.97

0.97

0.97

0.96

0.97

0.97

0.97

0.97

1.03

1.03

1.03

1.03

1.03

1.04

1.03

1.03

≥ 1 year schooling (no)

1.91***

1.85***

1.91***

1.98***

1.85***

1.82***

1.85***

1.92***

0.85

0.82

0.85

0.87

0.90

0.86

0.93

0.91

Married (not married)

1.52

1.55

1.53

1.51

1.51

1.53

1.51

1.47

1.14

1.17

1.16

1.13

1.13

1.19

1.21

1.13

Close proximity to children (no)

0.89

0.88

0.89

0.86

0.87

0.87

0.87

0.84

0.93

0.93

0.93

0.91

0.92

0.92

0.92

0.91

Soc/leisure activity score ≥2 (<2)

1.94***

1.92***

1.89**

1.99***

1.98***

1.98***

1.97**

1.97***

2.18***

2.16***

1.86**

2.21***

2.13***

2.14***

1.19

2.12***

Regular exercise (no)

1.87***

1.21

1.87***

1.91***

1.86***

1.44

1.86***

1.90***

1.77***

1.05

1.76***

1.79***

1.79***

0.71

1.77***

1.80***

Negative emotion (no)

0.47***

0.46***

0.47***

0.73

0.48***

0.48***

0.48***

0.85

0.63***

0.62***

0.63***

0.87

0.61***

0.60***

0.62***

0.74

GxE interaction terms

                

ADRB2 x (exercise)

 

2.26**

   

1.44

   

2.68**

   

3.77***

  

p-value

 

0.026

   

0.358

   

0.013

   

0.002

  

ADRB2 x (social & leisure activity)

  

1.06

   

1.01

   

1.36

   

2.29**

 

p-value

  

0.873

   

0.978

   

0.398

   

0.034

 

ADRB2 x (negative emotion)

   

0.47**

   

0.45**

   

0.56*

   

0.77

p-value

   

0.014

   

0.022

   

0.076

   

0.474

LR chi2

 

4.96

0.03

6.02

 

0.84

0.00

5.23

 

6.20

0.72

3.15

 

9.61

4.47

5.94

Prob > chi2 (P)

 

0.03

0.87

0.01

 

0.36

0.98

0.02

 

0.01

0.40

0.08

 

0.00

0.03

0.48

−2LL (-2 log Likelihood)

1308.6

1303.6

1308.6

1302.6

1299.9

1299.1

1299.9

1294.7

907.5

901.3

906.8

904.4

901.1

891.5

896.6

900.6

  1. Notes: (1) *p < 0.1, **p < 0.05, ***p < 0.01. For all interaction terms tested, we also listed the exact p values. (2) LR chi2 is computed using model -A1 or –B1 as the benchmark.