Dependent variable | MMSE score (Good/moderate/Poor) | Self-reported good health | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(Model I, based on ordered logistic regression) | (Model II based on binary logistic regression) | |||||||||||||||
Genotype included in model | rs1042718 | rs1042719 | rs1042718 | rs1042719 | ||||||||||||
Model code | I-A1 | I-A2 | I-A3 | I-A4 | I-B1 | I-B2 | I-B3 | I-B4 | II-A1 | II-A2 | II-A3 | II-A4 | II-B1 | II-B2 | II-B3 | II-B4 |
rs1042718 carrier (non-carrier) | 1.00 | 0.83 | 0.99 | 1.54* | Â | Â | Â | Â | 1.12 | 0.91 | 1.03 | 1.57* | Â | Â | Â | Â |
rs1042719 carrier (non-carrier) | Â | Â | Â | Â | 1.04 | 0.96 | 1.04 | 1.65* | Â | Â | Â | Â | 0.97 | 0.73 | 0.77 | 1.14 |
Male (female) | 1.60** | 1.61** | 1.59** | 1.56** | 1.68*** | 1.68*** | 1.68*** | 1.65** | 1.42* | 1.42 | 1.41 | 1.40 | 1.39 | 1.39 | 1.36 | 1.37 |
Urban (rural) | 1.03 | 1.04 | 1.03 | 1.04 | 1.06 | 1.06 | 1.06 | 1.05 | 1.24 | 1.26 | 1.25 | 1.26 | 1.27 | 1.28 | 1.27 | 1.27 |
Age | 0.97 | 0.97 | 0.97 | 0.96 | 0.97 | 0.97 | 0.97 | 0.97 | 1.03 | 1.03 | 1.03 | 1.03 | 1.03 | 1.04 | 1.03 | 1.03 |
≥ 1 year schooling (no) | 1.91*** | 1.85*** | 1.91*** | 1.98*** | 1.85*** | 1.82*** | 1.85*** | 1.92*** | 0.85 | 0.82 | 0.85 | 0.87 | 0.90 | 0.86 | 0.93 | 0.91 |
Married (not married) | 1.52 | 1.55 | 1.53 | 1.51 | 1.51 | 1.53 | 1.51 | 1.47 | 1.14 | 1.17 | 1.16 | 1.13 | 1.13 | 1.19 | 1.21 | 1.13 |
Close proximity to children (no) | 0.89 | 0.88 | 0.89 | 0.86 | 0.87 | 0.87 | 0.87 | 0.84 | 0.93 | 0.93 | 0.93 | 0.91 | 0.92 | 0.92 | 0.92 | 0.91 |
Soc/leisure activity score ≥2 (<2) | 1.94*** | 1.92*** | 1.89** | 1.99*** | 1.98*** | 1.98*** | 1.97** | 1.97*** | 2.18*** | 2.16*** | 1.86** | 2.21*** | 2.13*** | 2.14*** | 1.19 | 2.12*** |
Regular exercise (no) | 1.87*** | 1.21 | 1.87*** | 1.91*** | 1.86*** | 1.44 | 1.86*** | 1.90*** | 1.77*** | 1.05 | 1.76*** | 1.79*** | 1.79*** | 0.71 | 1.77*** | 1.80*** |
Negative emotion (no) | 0.47*** | 0.46*** | 0.47*** | 0.73 | 0.48*** | 0.48*** | 0.48*** | 0.85 | 0.63*** | 0.62*** | 0.63*** | 0.87 | 0.61*** | 0.60*** | 0.62*** | 0.74 |
GxE interaction terms | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
ADRB2 x (exercise) | Â | 2.26** | Â | Â | Â | 1.44 | Â | Â | Â | 2.68** | Â | Â | Â | 3.77*** | Â | Â |
p-value | Â | 0.026 | Â | Â | Â | 0.358 | Â | Â | Â | 0.013 | Â | Â | Â | 0.002 | Â | Â |
ADRB2 x (social & leisure activity) | Â | Â | 1.06 | Â | Â | Â | 1.01 | Â | Â | Â | 1.36 | Â | Â | Â | 2.29** | Â |
p-value | Â | Â | 0.873 | Â | Â | Â | 0.978 | Â | Â | Â | 0.398 | Â | Â | Â | 0.034 | Â |
ADRB2 x (negative emotion) | Â | Â | Â | 0.47** | Â | Â | Â | 0.45** | Â | Â | Â | 0.56* | Â | Â | Â | 0.77 |
p-value | Â | Â | Â | 0.014 | Â | Â | Â | 0.022 | Â | Â | Â | 0.076 | Â | Â | Â | 0.474 |
LR chi2 | Â | 4.96 | 0.03 | 6.02 | Â | 0.84 | 0.00 | 5.23 | Â | 6.20 | 0.72 | 3.15 | Â | 9.61 | 4.47 | 5.94 |
Prob > chi2 (P) |  | 0.03 | 0.87 | 0.01 |  | 0.36 | 0.98 | 0.02 |  | 0.01 | 0.40 | 0.08 |  | 0.00 | 0.03 | 0.48 |
−2LL (-2 log Likelihood) | 1308.6 | 1303.6 | 1308.6 | 1302.6 | 1299.9 | 1299.1 | 1299.9 | 1294.7 | 907.5 | 901.3 | 906.8 | 904.4 | 901.1 | 891.5 | 896.6 | 900.6 |