Table 3 Any osteoporotic fracture outcomes according to baseline characteristics and treatment group
Baseline characteristic | B-Vitamins | Placebo | p-value | P-value for interaction | |
|---|---|---|---|---|---|
(n = 4089) | (n = 4075) | (log-rank test) | |||
N (%) | N (%) | ||||
Sex | Male | 27 (1.0) | 28 (1.1) | 0.90 | 0.50 |
Female | 40 (2.7) | 50 (3.4) | 0.21 | ||
Age | <65 yrs | 12 (0.6) | 11 (0.5) | 0.90 | 0.57 |
> = 65 yrs | 55 (2.8) | 67 (3.5) | 0.28 | ||
Ethnicity | Western European | 48 (2.9) | 57(3.5) | 0.35 | 0.65 |
Oriental | 9 (0.9) | 6 (0.6) | 0.42 | ||
South Asian | 4 (0.4) | 3 (0.3) | 0.74 | ||
Other | 1 (0.4) | 5 (1.7) | 0.12 | ||
Oxford Handicap Score | > = 3 | 14 (1.5) | 21 (2.2) | 0.18 | 0.34 |
<3 | 51 (1.7) | 56 (1.9) | 0.63 | ||
Smoking (ever) | Yes | 36 (1.8) | 36 (1.8) | 0.96 | 0.30 |
No | 31 (1.5) | 42 (2.1) | 0.16 | ||
Alcohol (any) | Yes | 26 (2.2) | 28 (2.5) | 0.71 | 0.76 |
No | 41 (1.4) | 50 (1.7) | 0.32 | ||
Diabetes | Yes | 9 (0.9) | 15 (1.6) | 0.21 | 0.34 |
No | 58 (1.9) | 63 (2.0) | 0.62 | ||
Stroke | Yes | 13 (2.1) | 15 (2.3) | 0.75 | 0.94 |
No | 54 (1.6) | 63 (1.9) | 0.38 | ||
Myocardial infarction | Yes | 8 (2.7) | 7 (2.3) | 0.71 | 0.49 |
No | 59 (1.6) | 71 (1.9) | 0.25 | ||
Hypertension | Yes | 48 (1.7) | 57 (2.0) | 0.40 | 0.98 |
No | 19 (1.6) | 21 (1.8) | 0.64 | ||
Depression | Yes | 8 (2.9) | 8 (3.0) | 0.83 | 0.51 |
No | 35 (1.0) | 49 (1.5) | 0.14 | ||
Antidepressant medication | Yes | 11 (4.0) | 13 (4.6) | 0.67 | 0.99 |
No | 56 (1.5) | 65 (1.8) | 0.37 | ||
Corticosteroid medication | Yes | 10 (3.3) | 13 (4.7) | 0.05 | 0.98 |
No | 57 (1.5) | 65 (1.7) | 0.46 | ||
Osteoporosis Medication | Yes | 4 (1.3) | 5 (1.8) | 0.37 | 0.62 |
No | 30 (0.8) | 31 (0.8) | 0.44 | ||
Homocysteine | < median | 10 (3.2) | 10 (3.5) | 0.77 | 0.81 |
(median 12.6 micromol/L) | (n = 595) | ||||
> = median | 8 (2.7) | 12 (3.8) | 0.53 | ||
(n = 610) |