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Table 4 Sensitivity analysis 1 of the relationships between both the eGFR at age 88 years and the decrease in the eGFR 3 years before (between age 85 and 88) and total and cardiovascular (CV) mortality

From: Prediction of mortality and functional decline by changes in eGFR in the very elderly: the Leiden 85-plus study

  

eGFR slope per year between 85 and 88 years in ml/min/1.73 m²/year

 

>-1

-1 to -2.99

-3 to -4.99

<-5

eGFR at age 88 > 60 (n=169)

 

n=128

n=26

n=12

n=3

Overall mortality

1 (ref)

1.35 (0.81-2.25)

2.09 (1.07-4.09)

2.43 (0.74-8.03)

CV mortality

1 (ref)

1.12 (0.41-3.08)

3.16 (1.12-8.90)

8.99 (2.34-34.60)

eGFR at age 88 45-59 (n=147)

 

n=71

n=46

n=21

n=9

Overall mortality

1 (ref)

0.70 (0.43-1.15)

1.07 (0.56-2.05)

2.31 (1.06-5.06)

CV mortality

1 (ref)

0.79 (0.34-1.88)

0.55 (1.39-2.12)

2.87 (0.84-9.82)

eGFR at age 88 < 45 (n=62)

 

n=20

n=21

n=14

n=7

Overall mortality

1 (ref)

0.60 (0.29-1.23)

0.48 (0.16-1.40)

1.77 (0.52-6.10)

CV mortality

1 (ref)

0.91 (0.34-2.39)

0.31 (0.04-2.42)

4.00 (1.04-15.43)

  1. The results are presented as the HR (95% CI) and were adjusted for the eGFR at age 88 and gender. The results are shown with one reference group for each eGFR subgroup.
  2. * No events.