- Meeting abstract
- Open Access
The effect of age on long-term survival after pancreatic resection for pancreatic cancer
© Beltrame et al; licensee BioMed Central Ltd. 2011
Published: 24 August 2011
The incidence of pancreatic cancer is increasing, and an increasing proportion of patients with pancreatic carcinoma is older than 75 years. After surgical resection remains the treatment of choice for pancreatic neoplasms, an increasing number of elderly patients are being referred for pancreatic resection. Although in the early 1990s there was rarely an indication for major pancreatic resection in the elderly because of the high postoperative complication rate, mortality and limited survival time , more recently an acceptable morbidity rate and late outcome in patients with advanced age have been reported [2, 3]. This retrospective study analyzed the effect of age on the survival of patients who underwent resection for pancreatic cancer.
Materials and methods
Data were collected on 212 consecutive patients who underwent pancreatic resection between January 2000 and July 2009 in our department, divided into two groups: group 1, patients under 75 years of age, and group 2, patients 75 years of age or older. The two groups were compared in terms of demographic features, comorbidities, and surgical procedures. All of the patients underwent standardized preoperative assessment of general medical conditions, blood tests, tumor marker CA 19-9 determination, abdominal CT scan, and when needed, magnetic resonance imaging or positron emission tomography. Surgical techniques included pylorus-preserving pancreaticoduodenectomy for tumors of the head, of the pancreas and distal splenopancreatectomy for tumors located in the body or tail. Total pancreatectomy was reserved for microscopic invasion of the line of resection. The morbidity and mortality rate included all complications or deaths after surgery until discharge from hospital. Age, stage, lymph node status, grading and radicality of resection were recorded as potentially prognostic factors. Statistical analysis was performed using the SPSS for Windows rel. 15.0. Patient overall survival and disease-free survival (DFS) were evaluated using the Kaplan-Meier method and compared with Log-Rank test. Independent prognostic variables were examined with Cox regression analysis. Statistical significance was considered as p< 0.05.
Clinical findings of patients who underwent resection for pancreatic cancer.
<75 yrs (n=163)
>75 yrs (n=49)
Median survival (months)
The results of the present study strongly suggest that age should not be considered as a contraindication for major pancreatic resection in pancreatic cancer patients. Postoperative morbidity and mortality are not statistically different in the two age groups. Similarly, disease-free and overall survival of patients 75 years or older undergoing resection for pancreatic cancer are not substantially different from the survival expected in younger patients.
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