- Meeting abstract
- Open Access
Optimization of long-term graft survival after liver transplantation: the role of donor age
© Lai et al; licensee BioMed Central Ltd. 2011
- Published: 24 August 2011
- Aged Donor
- Graft Survival Rate
- Prolonged Waiting
- Consecutive Liver
- Viral Recurrence
Nowadays, several solutions have been proposed for the minimization of both organ shortage and prolonged waiting times: the expansion of the donor pool using aged donors represents a possible solution . However, it is not completely clear if the use of “extreme” donors could cause unacceptable post-transplant adjunctive risks . Starting from these grounds, the aim of this study is to evaluate the impact of donor age on long-term graft survival.
From January 2001 to April 2009, 188 consecutive liver transplantations were performed at our Department. The entire cohort was stratified in 4 subgroups according to donor age: Group 1 (1st-2nd decade, n=34), Group 2 (3rd-4th decade, n=51), Group 3 (5th-6th decade, n=75) and Group 4 (7th-8th decade, n=28). Donor, recipient and transplantation characteristics were compared in the 4 groups. ANOVA test and Kruskal-Wallis test were used for the comparison of continuous and categorical variables. Kaplan-Meier test was adopted for survival analysis: log-rank test was used for comparison among the groups’ survival rates.
In our experience, use of < 70 year-aged donors seems to be safe, while very aged (over 70) donors give poor long-term survival rates, despite similar initial post-transplantation results. We could speculate that grafts procured by very aged donors could be easier targets of viral recurrence, late ischemia-reperfusion damage and chronic rejection. A better allocation system for these organs may be improved, preferring HCC recipients who exceed transplant criteria to HCV ones .
- Pirenne J, Monbaliu D, Van Gelder F, Van Hees D, Aerts R, Verslype C, et al: Liver transplantation using livers from septuagenarian and octogenarian donors: an underused strategy to reduce mortality on the waiting list. Transplant Proc. 2005, 37: 1180-1. 10.1016/j.transproceed.2004.12.168.View ArticlePubMedGoogle Scholar
- Tector AJ, Mangus RS, Chestovich P, Vianna R, Fridell JA, Milgrom ML, et al: Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival. Ann Surg. 2006, 244: 439-50.PubMed CentralPubMedGoogle Scholar
- Sotiropoulos GC, Paul A, Molmenti E, Lang H, Frilling A, Napieralski BP, et al: Liver transplantation for hepatocellular carcinoma in cirrhosis within the Eurotransplant area: an additional option with "livers that nobody wants". Transpl. 2005, 80: 897-902. 10.1097/01.TP.0000173644.63692.DC.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.