Inclusion criteria | Exclusion criteria |
---|---|
Age ≥ 55 Competency in English sufficient for assessment and training Community-dwelling MMSE^ 23-29 CDR^^ ≤ 1.0 TICS #< 30 No unstable disease precluding planned exercise* Absence of significant cognitive decline in 5 years Absence of known organic or psychiatric condition affecting cognition Able to see and hear sufficiently to participate in planned physical and computer-based cognitive training | Unstable medical condition* Participation in any cognitive training activity Participation in > 150 min/wk of moderate or greater intensity planned exercise of any kind Rapidly progressive or terminal illness Pre-existing diagnosis of dementia Psychotic illness (DSM-IV)** Degenerative neurological disorder Diagnosis of stroke or TIA+ within last 12 months, stroke with residual neurological deficit, two or more strokes or TIAs at anytime, One stroke or TIA with residual deficits that preclude participation. TBI ± within past year, or with residual deficits that preclude participation. Diagnosis of depression (DSM-IV) GDS++ >9 or current treatment with antidepressant medications, greater than 3 episodes of depression in the last 5 years ("episode": requiring treatment), > 10 episodes requiring treatment over lifetime, past suicide attempts, current bipolar diagnosis and treatment, > 3 past episodes requiring treatment in last 5 years. Current alcohol or drug abuse (DSM-IV) Unrepaired abdominal or other known aneurysm Myocardial infarction or cardiac surgery within past 6 months NYHA Class IV CHF±± Unstable angina or uncontrolled malignant arrhythmias at rest or on exercise stress testing Recent retinal haemorrhage or detachment/proliferative retinopathy Seizures (>2 in past 12 months) |