- G Nicoletti1
© Nicoletti; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
Differential diagnosis of parkinsonian sindrome is a major challenge in movement disorders because at the onset there is an overlapping of signs and syntoms. From a neuropathological point of view, parkinsonism may be related to a degeneration of the nigrostriatal pathway or the neurodegenerative process may be more widespread [1, 2]. In the early course of the a disease presenting with parkinsonian symptoms, differentiation between these disorders may be difficult, [3, 4], but the clinical diagnostic criteria become more applicable during later stages. Motor symptoms (bradikynesia, tremor at rest, rigidity) may be asoociated to cognitive disfunction. Sporadic parkinsonism may be distinguished in:) Multiple system atrophy (MSA), Progressive supranuclear palsy (PSP), Corticobasal degeneration, and Lewy body dementia [3, 5, 6].
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