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Volume 10 Supplement 1

de Senectute: Age and Health Forum

  • Meeting abstract
  • Open Access

Use of platelet gel for the treatment of diabetic foot ulcers

  • 1
BMC Geriatrics201010 (Suppl 1) :A76

https://doi.org/10.1186/1471-2318-10-S1-A76

  • Published:

Keywords

  • Skin Graft
  • Ulcer Healing
  • Healing Time
  • Complete Healing
  • Fast Discharge

Background

The aim of this paper is to evaluate the efficacy of platelet gel also for the management of “diabetic foot” lesions. The most important principle considered in this work is the activity of several tissue growth factors inside the pattern of gel.

Materials and methods

During a period of 4 years, we have considered 42 patients aged between 65 and 75 (F:M 3:1), all submitted to other therapeutic options with failure of previous therapy, Table 1.

Table 1

Clinical presentation

Nr Cases

Stump dehiscence

8

Arterial ulcers

14

Neuropathic ulcers

20

The platelet gel is produced from concentrated PLT obtained with different procedures. These derive from the amount of required PTLs, mixed and gelled with Ca-gluconate. The combination with trombin allows the activation of gel. This active gel is immediately put on the lesions.

The following therapeutic scheme is mandatory for the correct practice:

1) antisepsis, cleansing, debridement and monitoring of exudate; 2) application of platelet gel; 3) weekly monitoring of lesions, Table 2

Table 2

Pathogenesis of ulcer

Nr Cases treated with platelet gel

Healing within 12 months

Dehiscence

8

6

Ischemic

14

10

Diabetic

20

14

TOTAL

42

30

Results

Among the patients presenting stump dehiscence and arterial ulcers healing time has been long (from 4 to 6 months) but satisfactory. The best results have been observed in patients with neuropathic ulcers, if we consider the healing time of the wound within 6 months from the start of treatment. Of these 20 patients, 14 have presented a complete healing of wounds, 3 undergone a smaller amputation and 3 undergone a bigger amputation, after six months starting treatment.

Conclusions

The platelet gel may be considered an additional and innovative "weapon" available for the treatment of chronic skin lesions due to ulcers in "non responders" patients to ordinary therapies. It can be clearly considered a useful complement to the most popular and successful alternative therapeutic techniques nowadays in use (advanced dressings, skin grafts, etc.). Another significant feature is related to fast discharge of patients: this represents a very important socioeconomic aspect. The platelet gel dressing is a safe and not expensive technique with rapid healing times; its use should be considered on a large scale.

Authors’ Affiliations

(1)
Chair of General Surgery –Vascular Surgery Training Programme, University Magna Graecia of Catanzaro, Italy

References

  1. American Diabetes Association: Preventive Foot Care in Diabetes(PS). Diabetes care. 2004, 27 (Suppl1): S63-S54.Google Scholar

Copyright

© Russo; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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