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Volume 10 Supplement 1

de Senectute: Age and Health Forum

Thromboembolic tendency (TE) in IBD (inflammatory bowel disease) patients

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Background

The incidence of TE events in IBD patients is higher than in population control [1, 2].

The main reason for this, is the hypercoaugulable state [3, 4].

Our aim was to detect serum markers related to TE, that can assume preventing and prognostic meanings.

Materials and methods

We performed a 3 year study on 71 patients with IBD, evaluating hypercoaugulability, and then we compared the results with 71 patients non IBD group control.

We also investigated patients of both groups concerning TE events occurred already.

Results

In IBD group we found out that 16 patients (22.5%) had a history of TE versus >1% of group control.

19 of them, already had knowledge of their previous hypercoaugulating condition.

48 (67%) had increased markers value versus less then 6% detected in group control.

In IBD group 43% ,20% and 4.2% had respectively 1, 1-3 or > 3 markers higher levels then normal range.

Among the markers investigated, we detected increased levels of plated in 33%, homocysteine in 26.7%, d-dimero 25.3%, c3 in 15.4%, apcr in 5.6%.

Conclusions

From our study we detected a higher incidence of TE events, and hypercoaugulating status in IBD group. In our previous investigations, plated, homocysteine, d-dimero, c3, and apcr, seemed to be the TE markers with higher sensibility.

It seems reasonable, according our experience, to propose a new TE risk score index for IBD patients:

low, mild and high risk respectively for patients with 1 , 1-3 and >3 markers with higher serum levels then normal range.

References

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    FarroKhyar F, Jan Irvine E, Swarbrick ET: A critical review of epidemiological studies in inflammatory bowel disease. Scand. J Gastroenterol. 2001, 1: 2-15. 10.1080/00365520150218002.

  2. 2.

    Bernstein CN, Wajda A, Blanchard JF: The incidence of arterial thromboembolic diseases in inflammatory bowel disease: a population-based study. Clin Gastroenterol Hepatol. 2008, 6: 41-45. 10.1016/j.cgh.2007.09.016.

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    Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, Grisak J, Machold K, Scholz S, Vogelsang H, Novacek G: Is IBD an independent risk factor for thromboembolism. Gut. 2004, 53: 542-548. 10.1136/gut.2003.025411.

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    Webberley MJ, Hart MT, Melikian V: Thromboembolism in inflammatory bowel disease: role of platelets. Gut. 1993, 34 (z): 247-251. 10.1136/gut.34.2.247.

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Author information

Correspondence to A Canero.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Canero, A., Goffredi, L. & Apperti, M. Thromboembolic tendency (TE) in IBD (inflammatory bowel disease) patients. BMC Geriatr 10, A51 (2010) doi:10.1186/1471-2318-10-S1-A51

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Keywords

  • High Risk
  • Serum Level
  • Inflammatory Bowel Disease
  • Bowel Disease
  • Homocysteine